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Science 18 July 1986:
Vol. 233. no. 4761, pp. 305 - 312
DOI: 10.1126/science.3014651
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Articles

Science, Vol 233, Issue 4761, 305-312
Copyright © 1986 by American Association for the Advancement of Science

articles

Studies and perspectives of protein kinase C

Y Nishizuka

Protein kinase C, an enzyme that is activated by the receptor-mediated hydrolysis of inositol phospholipids, relays information in the form of a variety of extracellular signals across the membrane to regulate many Ca2+-dependent processes. At an early phase of cellular responses, the enzyme appears to have a dual effect, providing positive forward as well as negative feedback controls over various steps of its own and other signaling pathways, such as the receptors that are coupled to inositol phospholipid hydrolysis and those of some growth factors. In biological systems, a positive signal is frequently followed by immediate negative feedback regulation. Such a novel role of this protein kinase system seems to give a logical basis for clarifying the biochemical mechanism of signal transduction, and to add a new dimension essential to our understanding of cell-to-cell communication.


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J. Clin. Endocrinol. Metab. 86, 3237-3242
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Phorbol Ester-Induced Inhibition of Potassium Currents in Rat Sensory Neurons Requires Voltage-Dependent Entry of Calcium.
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   Abstract »    Full Text »    PDF »
Development of High Throughput Screening Assays Using Fluorescence Polarization: Nuclear Receptor-Ligand-Binding and Kinase/Phosphatase Assays.
G. J. Parker, T. L. Law, F. J. Lenoch, and R. E. Bolger (2000)
J Biomol Screen 5, 77-88
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Synergistic Epithelial Responses to Endotoxin and a Naturally Occurring Muramyl Peptide.
T. A. Flak, L. N. Heiss, J. T. Engle, and W. E. Goldman (2000)
Infect. Immun. 68, 1235-1242
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PKC Isoenzymes in the Chicken Lens and TPA-Induced Effects on Intercellular Communication.
V. M. Berthoud, E. M. Westphale, A. Grigoryeva, and E. C. Beyer (2000)
Invest. Ophthalmol. Vis. Sci. 41, 850-858
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Ceramides as Key Players in Cellular Stress Response.
J. Pfeilschifter and A. Huwiler (2000)
Physiology 15, 11-15
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Cholinergic-Induced Ca2+ Elevation in Rat Lacrimal Gland Acini Is Negatively Modulated by PKC{delta} and PKC{epsilon}.
D. Zoukhri, R. R. Hodges, C. Sergheraert, and D. A. Dartt (2000)
Invest. Ophthalmol. Vis. Sci. 41, 386-392
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p38 MAP Kinase Is Required for Vasopressin-Stimulated HSP27 Induction in Aortic Smooth Muscle Cells.
T. Ito, O. Kozawa, K. Tanabe, M. Niwa, H. Matsuno, N. Sakai, H. Ito, K. Kato, and T. Uematsu (2000)
Hypertension 35, 673-678
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Mechanisms Controlling the Function and Life Span of the Corpus Luteum.
G. D. Niswender, J. L. Juengel, P. J. Silva, M. K. Rollyson, and E. W. McIntush (2000)
Physiol Rev 80, 1-29
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Protein kinase C is involved in enhanced airway smooth muscle cell growth in hyperresponsive rats.
M. E. Zacour and J. G. Martin (2000)
Am J Physiol Lung Cell Mol Physiol 278, L59-L67
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Adenosine A1 and Class II Metabotropic Glutamate Receptors Mediate Shared Presynaptic Inhibition of Retinotectal Transmission.
C. Zhang and J. T. Schmidt (1999)
J Neurophysiol 82, 2947-2955
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