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Science 15 August 1986:
Vol. 233. no. 4765, pp. 786 - 788
DOI: 10.1126/science.3738510
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Articles

Science, Vol 233, Issue 4765, 786-788
Copyright © 1986 by American Association for the Advancement of Science

articles

Chromosome Y-specific DNA is transferred to the short arm of X chromosome in human XX males

M Andersson, DC Page, and A de la Chapelle

Y-chromosomal DNA is present in the genomes of most human XX males. In these cases, maleness is probably due to the presence of the Y-encoded testis-determining factor (TDF). By means of in situ hybridization of a probe (pDP105) detecting Y-specific DNA to metaphases from three XX males, it was demonstrated that the Y DNA is located on the tip of the short arm of an X chromosome. This finding supports the hypothesis that XX maleness is frequently the result of transfer of Y DNA, including TDF, to a paternally derived X chromosome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. Lange, H. Skaletsky, G. W. Bell, and D. C. Page (2008)
Nucleic Acids Res. 36, D809-D814
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Clinical, Endocrinological, and Epigenetic Features of the 46,XX Male Syndrome, Compared with 47,XXY Klinefelter Patients.
E. Vorona, M. Zitzmann, J. Gromoll, A. N. Schuring, and E. Nieschlag (2007)
J. Clin. Endocrinol. Metab. 92, 3458-3465
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Profile of David C. Page.
B. Trivedi (2006)
PNAS 103, 2471-2473
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Pre-Sertoli Specific Gene Expression Profiling Reveals Differential Expression of Ppt1 and Brd3 Genes Within the Mouse Genital Ridge at the Time of Sex Determination.
A. Boyer, J. G. Lussier, A. H. Sinclair, P. J. McClive, and D. W. Silversides (2004)
Biol Reprod 71, 820-827
   Abstract »    Full Text »    PDF »
Identification of a second pseudoautosomal region near the Xq and Yq telomeres.
D Freije, C Helms, M. Watson, and H Donis-Keller (1992)
Science 258, 1784-1787
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