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Science 31 July 1987:
Vol. 237. no. 4814, pp. 527 - 532
DOI: 10.1126/science.3037705
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Articles

Science, Vol 237, Issue 4814, 527-532
Copyright © 1987 by American Association for the Advancement of Science

articles

Identification of a family of muscarinic acetylcholine receptor genes

TI Bonner, NJ Buckley, AC Young, and MR Brann

Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian cells. Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence. This gene family provides a new basis for evaluating the diversity of muscarinic mechanisms in the nervous system.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)