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Science 28 August 1987:
Vol. 237. no. 4818, pp. 999 - 1006
DOI: 10.1126/science.3616631
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Articles

Science, Vol 237, Issue 4818, 999-1006
Copyright © 1987 by American Association for the Advancement of Science

articles

Chemistry of pheromone and hormone metabolism in insects

GD Prestwich

Chemical evidence is needed in both insect endocrinology and sensory physiology to understand hormone and pheromone action at the molecular level. Radiolabeled pheromones and hormones have been synthesized and used to identify binding and catabolic proteins from insect tissues. Chemically modified analogs, including photoaffinity labels and enzyme inhibitors, are among the tools used to covalently modify the specific acceptor or catalytic sites. Such targeted agents can also provide leads for the design of growth and mating disruptants by allowing manipulation of the physiologically important interactions of the chemical signals with macromolecules.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)