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Science 8 July 1988:
Vol. 241. no. 4862, pp. 202 - 205
DOI: 10.1126/science.3260404
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Articles

Science, Vol 241, Issue 4862, 202-205
Copyright © 1988 by American Association for the Advancement of Science

articles

Identification of a putative regulator of early T cell activation genes

JP Shaw, PJ Utz, DB Durand, JJ Toole, EA Emmel, and GR Crabtree

Howard Hughes Medical Institute, Stanford University, CA 94305.

Molecules involved in the antigen receptor-dependent regulation of early T cell activation genes were investigated with the use of functional sequences of the T cell activation-specific enhancer of interleukin-2 (IL-2). One of these sequences forms a protein complex, NFAT-1, specifically with nuclear extracts of activated T cells. This complex appeared 10 to 25 minutes before the activation of the IL-2 gene. Studies with inhibitors of protein synthesis indicated that the time of synthesis of the activator of the IL-2 gene in Jurkat T cells corresponds to the time of appearance of NFAT-1. NFAT-1, or a very similar protein, bound functional sequences of the long terminal repeat (LTR) of the human immunodeficiency virus type 1; the LTR of this virus is known to be stimulated during early T cell activation. The binding site for this complex activated a linked promoter after transfection into antigen receptor-activated T cells but not other cell types. These characteristics suggest that NFAT-1 transmits signals initiated at the T cell antigen receptor.


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Induction of NFAT-mediated Transcription by G(q)-coupled Receptors in Lymphoid and Non-lymphoid Cells.
V. Boss, D. J. Talpade, and T. J. Murphy (1996)
J. Biol. Chem. 271, 10429-10432
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Activation of Nuclear Factor of Activated T Cells in a Cyclosporin A-resistant Pathway.
P. Ghosh, A. Sica, M. Cippitelli, J. Subleski, R. Lahesmaa, H. A. Young, and N. R. Rice (1996)
J. Biol. Chem. 271, 7700-7704
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Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells.
C. C. W. Hughes and J. S. Pober (1996)
J. Biol. Chem. 271, 5369-5377
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Identification of a Physical Interaction between Calcineurin and Nuclear Factor of Activated T Cells (NFATp).
S. Wesselborg, D. A. Fruman, J. K. Sagoo, B. E. Bierer, and S. J. Burakoff (1996)
J. Biol. Chem. 271, 1274-1277
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Identification of a Novel Repressive Element in the Proximal lck Promoter.
R. C. Muise-Helmericks and N. Rosen (1995)
J. Biol. Chem. 270, 27538-27543
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