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Science 8 July 1988:
Vol. 241. no. 4862, pp. 215 - 218
DOI: 10.1126/science.2455346

Articles

Science, Vol 241, Issue 4862, 215-218
Copyright © 1988 by American Association for the Advancement of Science


articles

Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits

ME Haberland, D Fong, and L Cheng

Department of Medicine, UCLA School of Medicine 90024.

It has been proposed that chemically reactive lipids released during lipid peroxidation convert low density lipoprotein (LDL), the major carrier of plasma cholesterol, to an abnormal form and that receptor-mediated clearance of this altered LDL produces cholesteryl ester deposition in macrophage-derived foam cells of atheroma. Immuno-cytochemical analyses now reveal the presence of protein modified by malondialdehyde, a peroxidative end product, which colocalizes with the extracellular deposition of apolipoprotein B-100 protein of LDL in atheroma from Watanabe heritable hyperlipidemic rabbits. These findings provide direct evidence for the existence in vivo of protein modified by a physiological product of lipid peroxidation within arterial lesions.


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L. Mabile, O. Meilhac, I. Escargueil-Blanc, M. Troly, M.-T. Pieraggi, R. Salvayre, and A. Negre-Salvayre (1997)
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S. L. Hazen, J. P. Gaut, F. F. Hsu, J. R. Crowley, A. d'Avignon, and J. W. Heinecke (1997)
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Autoantibodies Against Oxidized LDL Do Not Predict Atherosclerotic Vascular Disease in Non–Insulin-Dependent Diabetes Mellitus.
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Arterioscler. Thromb. Vasc. Biol. 16, 1236-1242
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Mildly Oxidized LDL Evokes a Sustained Ca2+-Dependent Retraction of Vascular Smooth Muscle Cells.
N. Auge, G. Fitoussi, J.-L. Bascands, M.-T. Pieraggi, D. Junquero, P. Valet, J.-P. Girolami, R. Salvayre, and A. Negre-Salvayre (1996)
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Oxidation-Specific Epitopes in Human Coronary Atherosclerosis Are Not Limited to Oxidized Low-Density Lipoprotein.
K. D. O'Brien, C. E. Alpers, J. E. Hokanson, S. Wang, and A. Chait (1996)
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N. Auge, N. Andrieu, A. Negre-Salvayre, J.-C. Thiers, T. Levade, and R. Salvayre (1996)
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M. Navab, J. A. Berliner, A. D. Watson, S. Y. Hama, M. C. Territo, A. J. Lusis, D. M. Shih, B. J. Van Lenten, J. S. Frank, L. L. Demer, et al. (1996)
Arterioscler. Thromb. Vasc. Biol. 16, 831-842
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Oxidized Lipids in the Diet Accelerate the Development of Fatty Streaks in Cholesterol-Fed Rabbits.
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Arterioscler. Thromb. Vasc. Biol. 16, 533-538
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   Abstract »    Full Text »
Inhibition of Lecithin-Cholesterol Acyltransferase and Modification of HDL Apolipoproteins by Aldehydes.
M. R. McCall, J. Y. Tang, J. K. Bielicki, and T. M. Forte (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 1599-1606
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Effect of the Antioxidant N,N'-Diphenyl 1,4-Phenylenediamine (DPPD) on Atherosclerosis in ApoE-Deficient Mice.
R. K. Tangirala, F. Casanada, E. Miller, J. L. Witztum, D. Steinberg, and W. Palinski (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 1625-1630
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Tissue Factor Pathway Inhibitor Activity Associated With LDL Is Inactivated by Cell- and Copper-Mediated Oxidation.
P. Lesnik, C. Dentan, A. Vonica, M. Moreau, and M. J. Chapman (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 1121-1130
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Immunologic Detection and Measurement of Hypochlorite-Modified LDL With Specific Monoclonal Antibodies.
E. Malle, L. Hazell, R. Stocker, W. Sattler, H. Esterbauer, and G. Waeg (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 982-989
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Inhibition of the Oxidative Modification of LDL by Nitecapone.
M. O. Pentikainen, K. A. Lindstedt, and P. T. Kovanen (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 740-747
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The Response-to-Retention Hypothesis of Early Atherogenesis.
K. J. Williams and I. Tabas (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 551-561
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Immunological Evidence for the Presence of Advanced Glycosylation End Products in Atherosclerotic Lesions of Euglycemic Rabbits.
W. Palinski, T. Koschinsky, S. W. Butler, E. Miller, H. Vlassara, A. Cerami, and J. L. Witztum (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 571-582
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Generation, Characterization, and Histochemical Application of Monoclonal Antibodies Selectively Recognizing Oxidatively Modified ApoB-Containing Serum Lipoproteins.
A. Hammer, G. Kager, G. Dohr, H. Rabl, I. Ghassempur, and G. Jurgens (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 704-713
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Prevention of Tocopherol-mediated Peroxidation in Ubiquinol-10-free Human Low Density Lipoprotein.
V. W. Bowry, D. Mohr, J. Cleary, and R. Stocker (1995)
J. Biol. Chem. 270, 5756-5763
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Lysine Modification of LDL or Lipoprotein(a) by 4-Hydroxynonenal or Malondialdehyde Decreases Platelet Serotonin Secretion Without Affecting Platelet Aggregability and Eicosanoid Formation.
E. Malle, A. Ibovnik, H. J. Leis, G. M. Kostner, P. F. J. Verhallen, and W. Sattler (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 377-384
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The Effect of {alpha}-Tocopherol Supplementation on LDL Oxidation : A Dose-Response Study.
I. Jialal, C. J. Fuller, and B. A. Huet (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 190-198
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