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Science 8 July 1988:
Vol. 241. no. 4862, pp. 221 - 223
DOI: 10.1126/science.2838907
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Articles

Science, Vol 241, Issue 4862, 221-223
Copyright © 1988 by American Association for the Advancement of Science

articles

Isoform-specific modulation of Na+, K+-ATPase alpha-subunit gene expression in hypertension

VL Herrera, AV Chobanian, and N Ruiz-Opazo

Section of Molecular Genetics, Boston University Medical Center, MA 02118.

Sodium, potassium-adenosine triphosphatase (Na+, K+-ATPase) is hypothesized to be involved in systemic vascular hypertension through its effects on smooth muscle reactivity and myocardial contractility. By means of RNA blot analyses of cardiac, aortic, and skeletal muscle RNAs in two rat hypertensive models, Na+,K+-ATPase alpha-subunit messenger RNA isoforms (alpha 2 and alpha 3) were shown to be deinduced in response to increased intravascular pressure. The changes were observed after 48 hours or more of experimental hypertension. Under these conditions, there is coordinate induction of another alpha isoform (alpha 1) and of beta-subunit messenger RNAs, probably in response to alterations in sodium flux rather than to elevated blood pressure.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)