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Science 22 July 1988:
Vol. 241. no. 4864, pp. 459 - 462
DOI: 10.1126/science.3393912
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Articles
Science, Vol 241, Issue 4864, 459-462
Copyright © 1988 by American Association for the Advancement of Science
Large microtubule-associated protein of T. brucei has tandemly repeated, near-identical sequences
A Schneider,
A Hemphill,
T Wyler,
and
T Seebeck
Institut fur allgemeine Mikrobiologie, Universitat Bern, Switzerland.
The parasitic protozoon Trypanosoma brucei contains a highly organized membrane skeleton, consisting of a dense array of parallel, singlet microtubules that are laterally interconnected and that are also in tight contact with the overlying cell membrane. A high molecular weight, heat-stable protein from this membrane skeleton was isolated that is localized along the microtubules. Protease digestion experiments and sequencing of a cloned gene segment showed that most of the protein is built up by more than 50 nearly identical tandem repeats with a periodicity of 38 amino acids.
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