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Science 22 July 1988:
Vol. 241. no. 4864, pp. 470 - 472
DOI: 10.1126/science.241.4864.470
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Articles

Science, Vol 241, Issue 4864, 470-472
Copyright © 1988 by American Association for the Advancement of Science

articles

RH 5849, a Nonsteroidal Ecdysone Agonist: Effects on Larval Lepidoptera

KEITH D. WING, RICHARD A. SLAWECKI, and GLENN R. CARLSON

Research Labs, Rohm and Haas Co., Spring House, PA 19477.

The ecdysone agonist RH 5849 (1,2-dibenzoyl-1-tert-butylhydrazine) causes the premature initiation of molting at all stages of larval development of the tobacco hornworm, Manduca sexta. This phenomenon occurs without an increase in the endogenous ecdysone (20-hydroxyecdysone) titers. RH 5849 likewise provokes the initiation of molting in larval abdomens in the absence of a source of endogenous hormone. Although substantially less active than 20-hydroxyecdysone in vitro, RH 5849 was 30 to >670 times as active as the authentic molting hormone in bioassays with isolated larval abdomens or intact hornworms. This reversal in potency can be attributed to the superior transport properties and metabolic stability of RH 5849 relative to 20-hydroxyecdysone. Thus RH 5849 and its analogs are relatively persistent ecdysone agonists that halt feeding in larval lepidoptera by forcing an ultimately lethal, developmentally premature molt.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The X-ray Structure of a Hemipteran Ecdysone Receptor Ligand-binding Domain: COMPARISON WITH A LEPIDOPTERAN ECDYSONE RECEPTOR LIGAND-BINDING DOMAIN AND IMPLICATIONS FOR INSECTICIDE DESIGN.
J. A. Carmichael, M. C. Lawrence, L. D. Graham, P. A. Pilling, V. C. Epa, L. Noyce, G. Lovrecz, D. A. Winkler, A. Pawlak-Skrzecz, R. E. Eaton, et al. (2005)
J. Biol. Chem. 280, 22258-22269
   Abstract »    Full Text »    PDF »
Reconstruction of Ligand-Dependent Transactivation of Choristoneura fumiferana Ecdysone Receptor in Yeast.
H. T. Tran, H. B. Askari, S. Shaaban, L. Price, S. R. Palli, T. S. Dhadialla, G. R. Carlson, and T. R. Butt (2001)
Mol. Endocrinol. 15, 1140-1153
   Abstract »    Full Text »    PDF »
Induction of Enzymes Involved in Molting Hormone (Ecdysteroid) Inactivation by Ecdysteroids and an Agonist, 1,2-Dibenzoyl-1-tert-butylhydrazine (RH-5849).
D. R. Williams, J.-H. Chen, M. J. Fisher, and H. H. Rees (1997)
J. Biol. Chem. 272, 8427-8432
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)