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Science 29 July 1988:
Vol. 241. no. 4865, pp. 582 - 585
DOI: 10.1126/science.3399893
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Articles
Science, Vol 241, Issue 4865, 582-585
Copyright © 1988 by American Association for the Advancement of Science
Selective activation of transcription by a novel CCAAT binding factor
SN Maity,
PT Golumbek,
G Karsenty,
and
B de Crombrugghe
Department of Molecular Genetics, Univesity of Texas, M.D. Anderson Cancer Center, Houston 77030.
A novel CCAAT binding factor (CBF) composed of two different subunits has been extensively purified from rat liver. Both subunits are needed for specific binding to DNA. Addition of this purified protein to nuclear extracts of NIH 3T3 fibroblasts stimulates transcription from several promoters including the alpha 2(I) collagen, the alpha 1(I) collagen, the Rous sarcoma virus long terminal repeat (RSV-LTR), and the adenovirus major late promoter. Point mutations in the CCAAT motif that show either no binding or a decreased binding of CBF likewise abolish or reduce activation of transcription by CBF. Activation of transcription requires, therefore, the specific binding of CBF to its recognition sites.
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