Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 July 1988:
Vol. 241. no. 4865, pp. 585 - 589
DOI: 10.1126/science.2969618

Articles

Science, Vol 241, Issue 4865, 585-589
Copyright © 1988 by American Association for the Advancement of Science


articles

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily

JE Sims, CJ March, D Cosman, MB Widmer, HR MacDonald, CJ McMahan, CE Grubin, JM Wignall, JL Jackson, SM Call, and al. et

Immunex Corporation, Seattle, WA 98101.

Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Peptide-Mediated Disruption of NF{kappa}B/NRF Interaction Inhibits IL-8 Gene Activation by IL-1 or Helicobacter pylori.
M. Bartels, A. T. Schweda, U. Dreikhausen, R. Frank, K. Resch, W. Beil, and M. Nourbakhsh (2007)
J. Immunol. 179, 7605-7613
   Abstract »    Full Text »    PDF »
Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.
R. O. Vogel, R. J.R.J. Janssen, M. A.M. van den Brand, C. E.J. Dieteren, S. Verkaart, W. J.H. Koopman, P. H.G.M. Willems, W. Pluk, L. P.W.J. van den Heuvel, J. A.M. Smeitink, et al. (2007)
Genes & Dev. 21, 615-624
   Abstract »    Full Text »    PDF »
Endometrial receptivity markers, the journey to successful embryo implantation.
H. Achache and A. Revel (2006)
Hum. Reprod. Update 12, 731-746
   Abstract »    Full Text »    PDF »
Intracellular IL-1{alpha}-binding proteins contribute to biological functions of endogenous IL-1{alpha} in systemic sclerosis fibroblasts.
Y. Kawaguchi, E. Nishimagi, A. Tochimoto, M. Kawamoto, Y. Katsumata, M. Soejima, T. Kanno, N. Kamatani, and M. Hara (2006)
PNAS 103, 14501-14506
   Abstract »    Full Text »    PDF »
Central IL-1 receptor signaling regulates bone growth and mass.
A. Bajayo, I. Goshen, S. Feldman, V. Csernus, K. Iverfeldt, E. Shohami, R. Yirmiya, and I. Bab (2005)
PNAS 102, 12956-12961
   Abstract »    Full Text »    PDF »
Shedding of the Type II IL-1 Decoy Receptor Requires a Multifunctional Aminopeptidase, Aminopeptidase Regulator of TNF Receptor Type 1 Shedding.
X. Cui, F. N. Rouhani, F. Hawari, and S. J. Levine (2003)
J. Immunol. 171, 6814-6819
   Abstract »    Full Text »    PDF »
The Interleukin 1 (IL-1) Receptor Accessory Protein Toll/IL-1 Receptor Domain: ANALYSIS OF PUTATIVE INTERACTION SITES BY IN VITRO MUTAGENESIS AND MOLECULAR MODELING.
J. Radons, S. Dove, D. Neumann, R. Altmann, A. Botzki, M. U. Martin, and W. Falk (2003)
J. Biol. Chem. 278, 49145-49153
   Abstract »    Full Text »    PDF »
Innate Immunity Mediated by the Cytokine IL-1 Homologue 4 (IL-1H4/IL-1F7) Induces IL-12-Dependent Adaptive and Profound Antitumor Immunity.
W. Gao, S. Kumar, M. T. Lotze, C. Hanning, P. D. Robbins, and A. Gambotto (2003)
J. Immunol. 170, 107-113
   Abstract »    Full Text »    PDF »
Antimicrobial Peptides Initiate IL-1{beta} Posttranslational Processing: A Novel Role Beyond Innate Immunity.
D. G. Perregaux, K. Bhavsar, L. Contillo, J. Shi, and C. A. Gabel (2002)
J. Immunol. 168, 3024-3032
   Abstract »    Full Text »    PDF »
Human Angiogenin Fused to Human CD30 Ligand (Ang-CD30L) Exhibits Specific Cytotoxicity against CD30-positive Lymphoma.
M. Huhn, S. Sasse, M. K. Tur, B. Matthey, T. Schinkothe, S. M. Rybak, S. Barth, and A. Engert (2001)
Cancer Res. 61, 8737-8742
   Abstract »    Full Text »    PDF »
Cycle-Dependent Expression of Interleukin-1 Receptor Type II in the Human Endometrium.
A. Boucher, A. Kharfi, M. Al-Akoum, P. Bossu, and A. Akoum (2001)
Biol Reprod 65, 890-898
   Abstract »    Full Text »    PDF »
Toll-like receptors (TLRs) signalling and expression pattern.
M. Muzio and A. Mantovani (2001)
Innate Immunity 7, 297-300
   Abstract »    PDF »
Two Novel IL-1 Family Members, IL-1{delta} and IL-1{epsilon}, Function as an Antagonist and Agonist of NF-{kappa}B Activation Through the Orphan IL-1 Receptor-Related Protein 2.
R. Debets, J. C. Timans, B. Homey, S. Zurawski, T. R. Sana, S. Lo, J. Wagner, G. Edwards, T. Clifford, S. Menon, et al. (2001)
J. Immunol. 167, 1440-1446
   Abstract »    Full Text »    PDF »
Involvement of Prostaglandin E2 in Interleukin-1{{alpha}}-Induced Parathyroid Hormone-Related Peptide Production in Synovial Fibroblasts of Patients with Rheumatoid Arthritis.
T. Yoshida, H. Sakamoto, T. Horiuchi, S. Yamamoto, A. Suematsu, H. Oda, and Y. Koshihara (2001)
J. Clin. Endocrinol. Metab. 86, 3272-3278
   Abstract »    Full Text »    PDF »
Resolution of pluripotential intermediates in murine hematopoietic differentiation by global complementary DNA amplification from single cells: confirmation of assignments by expression profiling of cytokine receptor transcripts.
F. Billia, M. Barbara, J. McEwen, M. Trevisan, and N. N. Iscove (2001)
Blood 97, 2257-2268
   Abstract »    Full Text »    PDF »
Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle.
F. Bigonnesse, M. Marois, R. Maheux, and A. Akoum (2001)
Mol. Hum. Reprod. 7, 333-339
   Abstract »    Full Text »    PDF »
Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis.
E. H.S. Choy and G. S. Panayi (2001)
N. Engl. J. Med. 344, 907-916
   Full Text »    PDF »
Interleukin (IL)-1{beta} Regulation of IL-1{beta} and IL-1 Receptor Antagonist Expression in Cultured Human Endometrial Stromal Cells.
H.-Y. Huang, Y. Wen, J. S. Kruessel, F. Raga, Y.-K. Soong, and M. L. Polan (2001)
J. Clin. Endocrinol. Metab. 86, 1387-1393
   Abstract »    Full Text »
Molecular Cloning and Expression of a Functionally Different Alternative Splice Variant of Prointerleukin-1{{alpha}} from the Rat Testis.
T. Sultana, K. Svechnikov, G. Weber, and O. Soder (2000)
Endocrinology 141, 4413-4418
   Abstract »    Full Text »    PDF »
IL-18 Receptors, Their Role in Ligand Binding and Function: Anti-IL-1RAcPL Antibody, a Potent Antagonist of IL-18.
R. Debets, J. C. Timans, T. Churakowa, S. Zurawski, R. de Waal Malefyt, K. W. Moore, J. S. Abrams, A. O'Garra, J. F. Bazan, and R. A. Kastelein (2000)
J. Immunol. 165, 4950-4956
   Abstract »    Full Text »    PDF »
Clostridium difficile Toxins Influence Hepatocyte Protein Synthesis Through the Interleukin 1 Receptor.
J. E. Mazuski, E. M. Grossmann, J. G. Norman, W. Denham, N. Panesar, M. J. Shapiro, R. L. Durham, D. L. Kaminski, and W. E. Longo (2000)
Arch Surg 135, 1206-1211
   Abstract »    Full Text »    PDF »
The Membrane Form of the Type II IL-1 Receptor Accounts for Inhibitory Function.
D. Neumann, C. Kollewe, M. U. Martin, and D. Boraschi (2000)
J. Immunol. 165, 3350-3357
   Abstract »    Full Text »    PDF »
Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein.
M. M. Sadeghi, M. Collinge, R. Pardi, and J. R. Bender (2000)
J. Immunol. 165, 2712-2718
   Abstract »    Full Text »    PDF »
Cloning of the Murine Thymic Stromal Lymphopoietin (TSLP) Receptor: Formation of a Functional Heteromeric Complex Requires Interleukin 7 Receptor.
L. S. Park, U. Martin, K. Garka, B. Gliniak, J. P. Di Santo, W. Muller, D. A. Largaespada, N. G. Copeland, N. A. Jenkins, A. G. Farr, et al. (2000)
J. Exp. Med. 192, 659-670
   Abstract »    Full Text »    PDF »
The Interleukin-1 Receptor/Toll-like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense.
L. A. J. O'Neill (2000)
Sci. STKE 2000, re1
   Abstract »    Full Text »    PDF »
Polarized Distribution of Interleukin-1 Receptors and Their Role in Regulation of Serotonin Transporter in Placenta.
R. Kekuda, F. H. Leibach, T. C. Furesz, C. H. Smith, and V. Ganapathy (2000)
J. Pharmacol. Exp. Ther. 292, 1032-1041
   Abstract »    Full Text »
Identification of Two Major Sites in the Type I Interleukin-1 Receptor Cytoplasmic Region Responsible for Coupling to Pro-inflammatory Signaling Pathways.
J. L. Slack, K. Schooley, T. P. Bonnert, J. L. Mitcham, E. E. Qwarnstrom, J. E. Sims, and S. K. Dower (2000)
J. Biol. Chem. 275, 4670-4678
   Abstract »    Full Text »    PDF »
IL-12 synergizes with IL-18 or IL-1{beta} for IFN-{gamma} production from human T cells.
K. Tominaga, T. Yoshimoto, K. Torigoe, M. Kurimoto, K. Matsui, T. Hada, H. Okamura, and K. Nakanishi (2000)
Int. Immunol. 12, 151-160
   Abstract »    Full Text »    PDF »
Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene.
M. J.H. Nicklin, D. E. Hughes, J. L. Barton, J. M. Ure, and G. W. Duff (2000)
J. Exp. Med. 191, 303-312
   Abstract »    Full Text »    PDF »
Four New Members Expand the Interleukin-1 Superfamily.
D. E. Smith, B. R. Renshaw, R. R. Ketchem, M. Kubin, K. E. Garka, and J. E. Sims (2000)
J. Biol. Chem. 275, 1169-1175
   Abstract »    Full Text »    PDF »
Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium.
D. H. Broide, K. Campbell, T. Gifford, and P. Sriramarao (2000)
Blood 95, 263-269
   Abstract »    Full Text »    PDF »
The interleukin-1 type I receptor is expressed in human hypothalamus.
E. A. Hammond, D. Smart, S. Toulmond, N. Suman-Chauhan, J. Hughes, and M. D. Hall (1999)
Brain 122, 1697-1707
   Abstract »    Full Text »    PDF »
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.
E. Kopp, R. Medzhitov, J. Carothers, C. Xiao, I. Douglas, C. A. Janeway, and S. Ghosh (1999)
Genes & Dev. 13, 2059-2071
   Abstract »    Full Text »
Recruitment of a Heparan Sulfate Subunit to the Interleukin-1 Receptor Complex. REGULATION BY FIBRONECTIN ATTACHMENT.
S. Valles, C. Tsoi, W.-Y. Huang, D. Wyllie, F. Carlotti, J. A. Askari, M. J. Humphries, S. K. Dower, and E. E. Qwarnstrom (1999)
J. Biol. Chem. 274, 20103-20109
   Abstract »    Full Text »    PDF »
Augmentation of Type I IL-1 Receptor Expression and IL-1 Signaling by IL-6 and Glucocorticoid in Murine Hepatocytes.
A. Ito, T. Takii, T. Matsumura, and K. Onozaki (1999)
J. Immunol. 162, 4260-4265
   Abstract »    Full Text »    PDF »
Bacterial Lipopolysaccharide Causes Rapid Shedding, Followed by Inhibition of mRNA Expression, of the IL-1 Type II Receptor, with Concomitant Up-Regulation of the Type I Receptor and Induction of Incompletely Spliced Transcripts.
G. Penton-Rol, S. Orlando, N. Polentarutti, S. Bernasconi, M. Muzio, M. Introna, and A. Mantovani (1999)
J. Immunol. 162, 2931-2938
   Abstract »    Full Text »    PDF »
The Type II IL-1 Receptor Interacts with the IL-1 Receptor Accessory Protein: A Novel Mechanism of Regulation of IL-1 Responsiveness.
D. Lang, J. Knop, H. Wesche, U. Raffetseder, R. Kurrle, D. Boraschi, and M. U. Martin (1998)
J. Immunol. 161, 6871-6877
   Abstract »    Full Text »    PDF »
Identification and functional importance of IL-1 receptors on rat parietal cells.
W. Schepp, K. Dehne, H. Herrmuth, K. Pfeffer, and C. Prinz (1998)
Am J Physiol Gastrointest Liver Physiol 275, G1094-G1105
   Abstract »    Full Text »    PDF »
Cyclic GMP and cGMP-binding Phosphodiesterase Are Required for Interleukin-1-induced Nitric Oxide Synthesis in Human Articular Chondrocytes.
Y. Geng, L. Zhou, W. J. Thompson, and M. Lotz (1998)
J. Biol. Chem. 273, 27484-27491
   Abstract »    Full Text »    PDF »
The Epstein-Barr Virus BARF1 Gene Encodes a Novel, Soluble Colony-Stimulating Factor-1 Receptor.
L. D. Strockbine, J. I. Cohen, T. Farrah, S. D. Lyman, F. Wagener, R. F. DuBose, R. J. Armitage, and M. K. Spriggs (1998)
J. Virol. 72, 4015-4021
   Abstract »    Full Text »    PDF »
Role of Metalloproteases in the Release of the IL-1 type II Decoy Receptor.
S. Orlando, M. Sironi, G. Bianchi, A. H. Drummond, D. Boraschi, D. Yabes, and A. Mantovani (1997)
J. Biol. Chem. 272, 31764-31769
   Abstract »    Full Text »    PDF »
IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling.
M. Muzio, J. Ni, P. Feng, and V. M. Dixit (1997)
Science 278, 1612-1615
   Abstract »    Full Text »
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.
J. Huang, X. Gao, S. Li, and Z. Cao (1997)
PNAS 94, 12829-12832
   Abstract »    Full Text »    PDF »
Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation.
T. Rauschmayr, R. W. Groves, and T. S. Kupper (1997)
PNAS 94, 5814-5819
   Abstract »    Full Text »    PDF »
Interleukin-1 Enhances the ATP-Evoked Release of Arachidonic Acid from Mouse Astrocytes.
N. Stella, A. Estelles, J. Siciliano, M. Tence, S. Desagher, D. Piomelli, J. Glowinski, and J. Premont (1997)
J. Neurosci. 17, 2939-2946
   Abstract »    Full Text »    PDF »
Lectin-like Characteristics of Recombinant Human Interleukin-1beta Recognizing Glycans of the Glycosylphosphatidylinositol Anchor.
K. Fukushima, S. Hara-Kuge, T. Ohkura, A. Seko, H. Ideo, T. Inazu, and K. Yamashita (1997)
J. Biol. Chem. 272, 10579-10584
   Abstract »    Full Text »    PDF »
Interleukin-1beta Induction of Mitogen-activated Protein Kinases in Human Mesangial Cells. ROLE OF OXIDATION.
W. A. Wilmer, L. C. Tan, J. A. Dickerson, M. Danne, and B. H. Rovin (1997)
J. Biol. Chem. 272, 10877-10881
   Abstract »    Full Text »    PDF »
The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases).
H. Wesche, C. Korherr, M. Kracht, W. Falk, K. Resch, and M. U. Martin (1997)
J. Biol. Chem. 272, 7727-7731
   Abstract »    Full Text »    PDF »
Interleukin-1-induced Growth Inhibition of Human Melanoma Cells. INTERLEUKIN-1-INDUCED ANTIZYME EXPRESSION IS RESPONSIBLE FOR ORNITHINE DECARBOXYLASE ACTIVITY DOWN-REGULATION.
D. Yang, H. Hayashi, T. Takii, Y. Mizutani, Y. Inukai, and K. Onozaki (1997)
J. Biol. Chem. 272, 3376-3383
   Abstract »    Full Text »    PDF »
Interleukin-1 Receptor and Receptor Antagonist Gene Expression After Focal Stroke in Rats.
X. Wang, F. C. Barone, N. V. Aiyar, G. Z. Feuerstein, and G. J. del Zoppo (1997)
Stroke 28, 155-162
   Abstract »    Full Text »
Dual Oncostatin M (OSM) Receptors. CLONING AND CHARACTERIZATION OF AN ALTERNATIVE SIGNALING SUBUNIT CONFERRING OSM-SPECIFIC RECEPTOR ACTIVATION.
B. Mosley, C. De Imus, D. Friend, N. Boiani, B. Thoma, L. S. Park, and D. Cosman (1996)
J. Biol. Chem. 271, 32635-32643
   Abstract »    Full Text »    PDF »
Detection and In Vivo Hormonal Regulation of Rat Ovarian Type I and Type II Interleukin-I Rececptor mRNAs: Increased Expression During the Periovulatory Period.
W. J. Scherzer, K. S. L. Ruutiainen-Altman, L. T. Putowski, S. Kol, E. Y. Adashi, and R. M. Rohan (1996)
Reproductive Sciences 3, 131-139
   Abstract »    PDF »
Interleukin-1 Induces Growth Arrest by Hypophosphorylation of the Retinoblastoma Susceptibility Gene Product RB.
S. Muthukkumar, S. F. Sells, S. A. Crist, and V. M. Rangnekar (1996)
J. Biol. Chem. 271, 5733-5740
   Abstract »    Full Text »    PDF »
T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family.
J. L. Mitcham, P. Parnet, T. P. Bonnert, K. E. Garka, M. J. Gerhart, J. L. Slack, M. A. Gayle, S. K. Dower, and J. E. Sims (1996)
J. Biol. Chem. 271, 5777-5783
   Abstract »    Full Text »    PDF »
IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP.
P. Parnet, K. E. Garka, T. P. Bonnert, S. K. Dower, and J. E. Sims (1996)
J. Biol. Chem. 271, 3967-3970
   Abstract »    Full Text »    PDF »
Differential Sensitivity of Interleukin-1alpha and -beta Precursor Proteins to Cleavage by Calpain, a Calcium-dependent Protease.
U. Kavita and S. B. Mizel (1995)
J. Biol. Chem. 270, 27758-27765
   Abstract »    Full Text »    PDF »
ST2/T1 Protein Functionally Binds to Two Secreted Proteins from Balb/c 3T3 and Human Umbilical Vein Endothelial Cells but Does Not Bind Interleukin 1.
S. Kumar, M. D. Minnich, and P. R. Young (1995)
J. Biol. Chem. 270, 27905-27913
   Abstract »    Full Text »    PDF »
Insertion of a Structural Domain of Interleukin (IL)-1beta Confers Agonist Activity to the IL-1 Receptor Antagonist.
S. A. Greenfeder, T. Varnell, G. Powers, K. Lombard-Gillooly, D. Shuster, K. W. McIntyre, D. E. Ryan, W. Levin, V. Madison, and G. Ju (1995)
J. Biol. Chem. 270, 22460-22466
   Abstract »    Full Text »    PDF »
Low Affinity Binding of Interleukin-1[IMAGE] and Intracellular Signaling via NF-[IMAGE]B Identify Fit-1 as a Distant Member of the Interleukin-1 Receptor Family.
A. Reikerstorfer, H. Holz, H. G. Stunnenberg, and M. Busslinger (1995)
J. Biol. Chem. 270, 17645-17648
   Abstract »    Full Text »    PDF »
NF-[IMAGE]B Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity.
G. E. Croston, Z. Cao, and D. V. Goeddel (1995)
J. Biol. Chem. 270, 16514-16517
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex.
S. A. Greenfeder, P. Nunes, L. Kwee, M. Labow, R. A. Chizzonite, and G. Ju (1995)
J. Biol. Chem. 270, 13757-13765
   Abstract »    Full Text »    PDF »
Interleukin-1-induced Calcium Flux in Human Fibroblasts Is Mediated through Focal Adhesions.
P. D. Arora, J. Ma, W. Min, T. Cruz, and C. A. G. McCulloch (1995)
J. Biol. Chem. 270, 6042-6049
   Abstract »    Full Text »    PDF »
Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.
F Colotta, F Re, M Muzio, R Bertini, N Polentarutti, M Sironi, J. Giri, S. Dower, J. Sims, and A Mantovani (1993)
Science 261, 472-475
   Abstract »    PDF »
Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta.
S Mathias, A Younes, C. Kan, I Orlow, C Joseph, and R. Kolesnick (1993)
Science 259, 519-522
   Abstract »    PDF »
Interleukin-6 and its receptor: a paradigm for cytokines.
T Kishimoto, S Akira, and T Taga (1992)
Science 258, 593-597
   Abstract »    PDF »
Molecular cloning of the interleukin-1 beta converting enzyme.
D. Cerretti, C. Kozlosky, B Mosley, N Nelson, K Van Ness, T. Greenstreet, C. March, Kronheim SR, T Druck, L. Cannizzaro, et al. (1992)
Science 256, 97-100
   Abstract »    PDF »
Enhancement of growth of virulent strains of Escherichia coli by interleukin-1.
R Porat, B. Clark, S. Wolff, and C. Dinarello (1991)
Science 254, 430-432
   Abstract »    PDF »
Structure and functional expression of a human interleukin-8 receptor.
W. Holmes, J Lee, W. Kuang, G. Rice, and W. Wood (1991)
Science 253, 1278-1280
   Abstract »    PDF »
Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo..
D S Schneider, K L Hudson, T Y Lin, and K V Anderson (1991)
Genes & Dev. 5, 797-807
   Abstract »    PDF »
Glycosylphosphatidylinositol: a candidate system for interleukin-2 signal transduction.
D. Eardley and M. Koshland (1991)
Science 251, 78-81
   Abstract »    PDF »
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
C. Smith, T Davis, D Anderson, L Solam, M. Beckmann, R Jerzy, S. Dower, D Cosman, and R. Goodwin (1990)
Science 248, 1019-1023
   Abstract »    PDF »
Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor.
W. Fanslow, J. Sims, H Sassenfeld, P. Morrissey, S Gillis, S. Dower, and M. Widmer (1990)
Science 248, 739-742
   Abstract »    PDF »
Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family.
N Itoh, S Yonehara, J Schreurs, D. Gorman, K Maruyama, A Ishii, I Yahara, K Arai, and A Miyajima (1990)
Science 247, 324-327
   Abstract »    PDF »
Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor.
P. Lee, D. Johnson, L. Cousens, V. Fried, and L. Williams (1989)
Science 245, 57-60
   Abstract »    PDF »
Signal transduction by the platelet-derived growth factor receptor.
L. Williams (1989)
Science 243, 1564-1570
   Abstract »    PDF »
Interleukin-6 Receptor and a Unique Mechanism of Its Signal Transduction.
T. Taga, M. Hibi, Y. Hirata, H. Yawata, S. Natsuka, K. Yasukawa, T. Totsuka, K. Yamasaki, T. Hirano, and T. Kishimoto (1989)
Cold Spring Harb Symp Quant Biol 54, 713-722
   Abstract »    PDF »



ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)