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Science 29 July 1988:
Vol. 241. no. 4865, pp. 593 - 595
DOI: 10.1126/science.2456614
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Articles
Science, Vol 241, Issue 4865, 593-595
Copyright © 1988 by American Association for the Advancement of Science
Conversion of normal behavior to shiverer by myelin basic protein antisense cDNA in transgenic mice
M Katsuki,
M Sato,
M Kimura,
M Yokoyama,
K Kobayashi,
and
T Nomura
Department of DNA Biology, School of Medicine, Tokai University, Isehara, Japan.
Myelin basic proteins (MBPs) are coded by the single gene necessary for myelin formation in the central nervous system of the mouse. An antisense MBP mini-gene was constructed and used to determine the function of antisense DNA in transgenic mice. Several transgenic offspring of a founder transgenic mouse, AS100, were converted from the normal to mutant shiverer phenotype. Antisense MBP messenger RNA was expressed in these mice, and the endogenous MBP messenger RNA, the MBP, and the myelination in the central nervous system were reduced.
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