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Science 5 August 1988:
Vol. 241. no. 4866, pp. 705 - 708
DOI: 10.1126/science.3041593
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Articles

Science, Vol 241, Issue 4866, 705-708
Copyright © 1988 by American Association for the Advancement of Science

articles

Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa

MC Rio, JP Bellocq, JY Daniel, C Tomasetto, R Lathe, MP Chenard, A Batzenschlager, and P Chambon

CNRS et U. 184 de l'INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France.

The human pS2 gene is specifically expressed under estrogen transcriptional control in a subclass of estrogen receptor-containing human breast cancer cells. The pS2 gene encodes an 84-amino acid protein that is secreted after signal peptide cleavage. The distribution of pS2 protein in normal human tissues was studied with antibodies to pS2; pS2 was specifically expressed and secreted by mucosa cells of the normal stomach antrum and body of both female and male individuals. Moreover, no estrogen receptor could be detected in these cells, indicating that pS2 gene expression is estrogen-independent in the stomach. The function of the pS2 protein in the gastrointestinal tract is unknown. However, the pS2 protein is similar in sequence to a porcine pancreatic protein that has been shown to inhibit gastrointestinal motility and gastric secretion.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)