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Science 12 August 1988:
Vol. 241. no. 4867, pp. 800 - 806
DOI: 10.1126/science.2841758
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Articles
Science, Vol 241, Issue 4867, 800-806
Copyright © 1988 by American Association for the Advancement of Science
From epinephrine to cyclic AMP
A Levitzki
Department of Biological Chemistry, Hebrew University of Jerusalem, Israel.
Binding of catecholamines to the beta-adrenergic receptor results in the activation of adenylate cyclase and the intracellular formation of adenosine 3',5'-monophosphate (cAMP). In the past 20 years the events that lead from hormone binding at the cell surface receptor site to the synthesis of cAMP at the inner layer of the membrane have been intensively studied. Signal transduction in this system involves the sequential interaction of the beta-adrenergic receptor with the guanine nucleotide-binding protein (Gs) and the adenylate cyclase catalyst (C). The mechanism of signal transduction from the receptor through Gs to C, as well as the role of the adenylate cyclase inhibitory G protein Gi, is discussed.
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