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Science 12 August 1988:
Vol. 241. no. 4867, pp. 832 - 835
DOI: 10.1126/science.3136547

Articles

Science, Vol 241, Issue 4867, 832-835
Copyright © 1988 by American Association for the Advancement of Science


articles

Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit

HE Hamm, D Deretic, A Arendt, PA Hargrave, B Koenig, and KP Hofmann

Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago 60680.

The interaction between receptors and guanine nucleotide binding (G) proteins leads to G protein activation and subsequent regulation of effector enzymes. The molecular basis of receptor-G protein interaction has been examined by using the ability of the G protein from rods (transducin) to cause a conformational change in rhodopsin as an assay. Synthetic peptides corresponding to two regions near the carboxyl terminus of the G protein alpha subunit, Glu311-Val328 and Ile340-Phe350, compete with G protein for interaction with rhodopsin. Amino acid substitution studies show that Cys321 is required for this effect. Ile340-Phe350 and a modified peptide, acetyl-Glu311-Lys329-amide, mimic G protein effects on rhodopsin conformation, showing that these peptides bind to and stabilize the activated conformation of rhodopsin.


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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S. Offermanns and M. I. Simon (1995)
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J Chen, M DeVivo, J Dingus, A Harry, J Li, J Sui, D. Carty, J. Blank, J. Exton, R. Stoffel, et al. (1995)
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