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Science 26 August 1988:
Vol. 241. no. 4869, pp. 1074 - 1077
DOI: 10.1126/science.3137657
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Articles

Science, Vol 241, Issue 4869, 1074-1077
Copyright © 1988 by American Association for the Advancement of Science

articles

Mitotic recombination within the centromere of a yeast chromosome

SW Liebman, LS Symington, and TD Petes

Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637.

Centromeres are the structural elements of eukaryotic chromosomes that hold sister chromatids together and to which spindle tubules connect during cell division. Centromeres have been shown to suppress meiotic recombination in some systems. In this study yeast strains genetically marked within and flanking a centromere, were used to demonstrate that gene conversion (nonreciprocal recombination) tracts in mitosis can enter into and extend through the centromere.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Centromere mitotic recombination in mammalian cells.
I. Jaco, A. Canela, E. Vera, and M. A. Blasco (2008)
J. Cell Biol. 181, 885-892
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)