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ArticlesCopyright © 1988 by American Association for the Advancement of Science
Two mechanisms for the extinction of gene expression in hybrid cells
Department of Molecular Biology, Massachusetts General Hospital, Boston.
When two different mammalian cell types are fused to generate a stable hybrid cell line, genes that are active in only one of the parents are frequently shut off, a phenomenon called extinction. In this study two distinct, complementary mechanisms for such extinction of growth hormone gene expression were identified. In hybrids formed by fusing fibroblasts to pituitary cells, pituitary-specific proteins that bind to the growth hormone promoter were absent. In addition, a negative regulatory element located near the rat growth hormone promoter was specifically activated.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
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