Science 2 September 1988: Vol. 241. no. 4870, pp. 1218 - 1221 DOI: 10.1126/science.2457950

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Articles

Neurokinin A engages neurokinin-1 receptor to induce NF-{kappa}B-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways.

J. Sun, R. D. Ramnath, R. Tamizhselvi, and M. Bhatia (2008)
Am J Physiol Cell Physiol 295, C679-C691
 |  Abstract »  |  Full Text »  |  PDF »

Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation.

R H Straub, F Grum, U Strauch, S Capellino, F Bataille, A Bleich, W Falk, J Scholmerich, and F Obermeier (2008)
Gut 57, 911-921
 |  Abstract »  |  Full Text »  |  PDF »

Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia.

S. W. Ng, H. Zhang, A. Hegde, and M. Bhatia (2008)
J. Leukoc. Biol. 83, 288-295
 |  Abstract »  |  Full Text »  |  PDF »

Intestinal Immune Response to Human Cryptosporidium sp. Infection.

B. Pantenburg, S. M. Dann, H.-C. Wang, P. Robinson, A. Castellanos-Gonzalez, D. E. Lewis, and A. C. White Jr. (2008)
Infect. Immun. 76, 23-29
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Lower density of synovial nerve fibres positive for calcitonin gene-related peptide relative to substance P in rheumatoid arthritis but not in osteoarthritis.

M. Dirmeier, S. Capellino, T. Schubert, P. Angele, S. Anders, and R. H. Straub (2008)
Rheumatology 47, 36-40
 |  Abstract »  |  Full Text »  |  PDF »

Urotensin II is a New Chemotactic Factor for UT Receptor-Expressing Monocytes.

J.-P. Segain, M. Rolli-Derkinderen, N. Gervois, D. Raingeard de la Bletiere, G. Loirand, and P. Pacaud (2007)
J. Immunol. 179, 901-909
 |  Abstract »  |  Full Text »  |  PDF »

G-protein-coupled receptor expression, function, and signaling in macrophages.

J. Lattin, D. A. Zidar, K. Schroder, S. Kellie, D. A. Hume, and M. J. Sweet (2007)
J. Leukoc. Biol. 82, 16-32
 |  Abstract »  |  Full Text »  |  PDF »

Spantide I Decreases Type I Cytokines, Enhances IL-10, and Reduces Corneal Perforation in Susceptible Mice after Pseudomonas aeruginosa Infection.

L. D. Hazlett, S. A. McClellan, R. P. Barrett, J. Liu, Y. Zhang, and S. Lighvani (2007)
Invest. Ophthalmol. Vis. Sci. 48, 797-807
 |  Abstract »  |  Full Text »  |  PDF »

Tachykinin-1 receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-{kappa}B via a Gq-dependent pathway.

R. Williams, X. Zou, and G. W. Hoyle (2007)
Am J Physiol Lung Cell Mol Physiol 292, L430-L437
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of neurokinin-1 receptor attenuates CC and CXC chemokine production in experimental acute pancreatitis and associated lung injury.

J. Sun and M. Bhatia (2007)
Am J Physiol Gastrointest Liver Physiol 292, G143-G153
 |  Abstract »  |  Full Text »  |  PDF »

Hypoxia upregulates lung microvascular neurokinin-1 receptor expression.

E. D. Zee, S. Schomberg, and T. C. Carpenter (2006)
Am J Physiol Lung Cell Mol Physiol 291, L102-L110
 |  Abstract »  |  Full Text »  |  PDF »

Relationship between substance P and interleukin-1{beta} in gingival crevicular fluid during orthodontic tooth movement in adults.

M. Yamaguchi, M. Yoshii, and K. Kasai (2006)
Eur J Orthod 28, 241-246
 |  Abstract »  |  Full Text »  |  PDF »

The effect of pain on leukocyte cellular adhesion molecules..

C. A. Griffis, P. Compton, and L. Doering (2006)
Biol Res Nurs 7, 297-312
 |  Abstract »  |  PDF »

Induction of colitis causes inflammatory responses in fat depots: Evidence for substance P pathways in human mesenteric preadipocytes.

I. Karagiannides, E. Kokkotou, M. Tansky, T. Tchkonia, N. Giorgadze, M. O'Brien, S. E. Leeman, J. L. Kirkland, and C. Pothoulakis (2006)
PNAS 103, 5207-5212
 |  Abstract »  |  Full Text »  |  PDF »

Preprotachykinin-A Gene Products Are Key Mediators of Lung Injury in Polymicrobial Sepsis.

P. Puneet, A. Hegde, S. W. Ng, H. Y. Lau, J. Lu, S. M. Moochhala, and M. Bhatia (2006)
J. Immunol. 176, 3813-3820
 |  Abstract »  |  Full Text »  |  PDF »

Neurokinin 1 Receptor Signaling Affects the Local Innate Immune Defense against Genital Herpes Virus Infection.

A. Svensson, J. Kaim, C. Mallard, A. Olsson, E. Brodin, T. Hokfelt, and K. Eriksson (2005)
J. Immunol. 175, 6802-6811
 |  Abstract »  |  Full Text »  |  PDF »

Real-Time Reverse Transcription-PCR Quantitation of Substance P Receptor (NK-1R) mRNA.

J.-P. Lai, S. D. Douglas, Y.-J. Wang, and W.-Z. Ho (2005)
Clin. Vaccine Immunol. 12, 537-541
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Immunoglobulin A Response and Protection against Salmonella enterica Serovar Typhimurium in the Absence of the Substance P Receptor.

N. Walters, T. Trunkle, M. Sura, and D. W. Pascual (2005)
Infect. Immun. 73, 317-324
 |  Abstract »  |  Full Text »  |  PDF »

Substance P Augments Borrelia burgdorferi-Induced Prostaglandin E2 Production by Murine Microglia.

A. Rasley, I. Marriott, C. R. Halberstadt, K. L. Bost, and J. Anguita (2004)
J. Immunol. 172, 5707-5713
 |  Abstract »  |  Full Text »  |  PDF »

Neurokinin-1 Receptor Antagonists Protect Mice from CD95- and Tumor Necrosis Factor-{alpha}-Mediated Apoptotic Liver Damage.

R. Bang, M. Biburger, W. L. Neuhuber, and G. Tiegs (2004)
J. Pharmacol. Exp. Ther. 308, 1174-1180
 |  Abstract »  |  Full Text »  |  PDF »

Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases.

R. H. STRAUB and H. O. BESEDOVSKY (2003)
FASEB J 17, 2176-2183
 |  Abstract »  |  Full Text »  |  PDF »

Virokinin, a Bioactive Peptide of the Tachykinin Family, Is Released from the Fusion Protein of Bovine Respiratory Syncytial Virus.

G. Zimmer, M. Rohn, G. P. McGregor, M. Schemann, K.-K. Conzelmann, and G. Herrler (2003)
J. Biol. Chem. 278, 46854-46861
 |  Abstract »  |  Full Text »  |  PDF »

Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice.

P. G. E. Kennedy, J. Rodgers, B. Bradley, S. P. Hunt, G. Gettinby, S. E. Leeman, C. De Felipe, and M. Murray (2003)
Brain 126, 1683-1690
 |  Abstract »  |  Full Text »  |  PDF »

The Three-Dimensional Distribution of Nerves Along the Entire Intrapulmonary Airway Tree of the Adult Rat and the Anatomical Relationship Between Nerves and Neuroepithelial Bodies.

S. D. Larson, E. S. Schelegle, D. M. Hyde, and C. G. Plopper (2003)
Am. J. Respir. Cell Mol. Biol. 28, 592-599
 |  Abstract »  |  Full Text »  |  PDF »

Toxic Rhinitis-Induced Changes of Human Nasal Mucosa Innervation.

D. A. Groneberg, W. Heppt, A. Cryer, A. Wussow, C. Peiser, M. Zweng, Q. Thai Dinh, C. Witt, and A. Fischer (2003)
Toxicol Pathol 31, 326-331
 |  Abstract »  |  PDF »

Neurokinin-1 Receptor Antagonists CP-96,345 and L-733,060 Protect Mice from Cytokine-Mediated Liver Injury.

R. Bang, G. Sass, A. K. Kiemer, A. M. Vollmar, W. L. Neuhuber, and G. Tiegs (2003)
J. Pharmacol. Exp. Ther. 305, 31-39
 |  Abstract »  |  Full Text »

Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter.

S. Simeonidis, I. Castagliuolo, A. Pan, J. Liu, C.-C. Wang, A. Mykoniatis, A. Pasha, L. Valenick, S. Sougioultzis, D. Zhao, et al. (2003)
PNAS 100, 2957-2962
 |  Abstract »  |  Full Text »  |  PDF »

Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States.

L. R. Watkins and S. F. Maier (2002)
Physiol Rev 82, 981-1011
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Inflammation of the Airways and Lung Parenchyma in COPD* : Role of T Cells.

M. G. Cosio, J. Majo, and M. G. Cosio (2002)
Chest 121, 160S-165S
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Airway Hyperresponsiveness by Calcitonin Gene-related Peptide in Allergen Sensitized and Challenged Mice.

A. Dakhama, A. Kanehiro, M. J. Makela, J. E. Loader, G. L. Larsen, and E. W. Gelfand (2002)
Am. J. Respir. Crit. Care Med. 165, 1137-1144
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE.

W-S Uhm, H-S Lee, Y-H Chung, T-H Kim, S-C Bae, K-B Joo, T-Y Kim, and D-H Yoo (2002)
Lupus 11, 227-233
 |  Abstract »  |  PDF »

An Opioid System in Connective Tissue: A Study of Achilles Tendon in the Rat.

P. W. Ackermann, M. Spetea, I. Nylander, K. Ploj, M. Ahmed, and A. Kreicbergs (2001)
J. Histochem. Cytochem. 49, 1387-1396
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Hypoxia-Inducible Factor-1{alpha} and Activation of Caspase-3 in Hypoxia-Reoxygenated Bone Marrow Stroma Is Negatively Regulated by the Delayed Production of Substance P.

J. Qian, K. Ramroop, A. McLeod, P. Bandari, D. H. Livingston, J. S. Harrison, and P. Rameshwar (2001)
J. Immunol. 167, 4600-4608
 |  Abstract »  |  Full Text »  |  PDF »

Disease of the airways in chronic obstructive pulmonary disease.

M.G. Cosio Piqueras and M.G. Cosio (2001)
Eur. Respir. J. 18, 41S-49s
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Mimicry between neurokinin-1 and fibronectin may explain the transport and stability of increased substance P immunoreactivity in patients with bone marrow fibrosis.

P. Rameshwar, D. D. Joshi, P. Yadav, J. Qian, P. Gascon, V. T. Chang, D. Anjaria, J. S. Harrison, and X. Song (2001)
Blood 97, 3025-3031
 |  Abstract »  |  Full Text »  |  PDF »

Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes.

J.-P. Lai, W.-Z. Ho, G.-X. Zhan, Y. Yi, R. G. Collman, and S. D. Douglas (2001)
PNAS 98, 3970-3975
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Nociceptin Stimulates Neutrophil Chemotaxis and Recruitment: Inhibition by Aspirin-Triggered-15-Epi-Lipoxin A4.

C. N. Serhan, I. M. Fierro, N. Chiang, and M. Pouliot (2001)
J. Immunol. 166, 3650-3654
 |  Abstract »  |  Full Text »  |  PDF »

The Sympathetic Nerve---An Integrative Interface between Two Supersystems: The Brain and the Immune System.

I. J. Elenkov, R. L. Wilder, G. P. Chrousos, and E. S. Vizi (2000)
Pharmacol. Rev. 52, 595-638
 |  Abstract »  |  Full Text »  |  PDF »

Substance P Differentially Stimulates IL-8 Synthesis in Human Corneal Epithelial Cells.

M. T. Tran, R. N. Lausch, and J. E. Oakes (2000)
Invest. Ophthalmol. Vis. Sci. 41, 3871-3877
 |  Abstract »  |  Full Text »

Lipopolysaccharide Enhances Substance P-mediated Neutrophil Adherence to Epithelial Cells and Cytokine Release.

H.-P. KUO, H.-C. LIN, K.-H. HWANG, C.-H. WANG, and L.-C. LU (2000)
Am. J. Respir. Crit. Care Med. 162, 1891-1897
 |  Abstract »  |  Full Text »

Substance P (Neurokinin-1) and Neurokinin A (Neurokinin-2) Receptor Gene and Protein Expression in the Healthy and Inflamed Human Intestine.

D. Renzi, B. Pellegrini, F. Tonelli, C. Surrenti, and A. Calabro (2000)
Am. J. Pathol. 157, 1511-1522
 |  Abstract »  |  Full Text »  |  PDF »

The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages.

L. E. MILLER, H.-P. JÜSTEN, J. SCHÖLMERICH, and R. H. STRAUB (2000)
FASEB J 14, 2097-2107
 |  Abstract »  |  Full Text »

Neurokinin-1 receptor expression in inflammatory bowel disease: molecular quantitation and localisation.

T Goode, J O'Connell, P Anton, H Wong, J Reeve, G C O'Sullivan, J K Collins, and F Shanahan (2000)
Gut 47, 387-396
 |  Abstract »  |  Full Text »  |  PDF »

Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis.

P Di Sebastiano, F F di Mola, C Di Febbo, G Baccante, E Porreca, P Innocenti, H Friess, and M W Buchler (2000)
Gut 47, 423-428
 |  Abstract »  |  Full Text »  |  PDF »

Recent aspects of gonadal hormone and neurotransmitter interactions with synovial and immune cells: implications in rheumatoid arthritis.

M. CUTOLO and R. H STRAUB (2000)
Ann Rheum Dis 59, 657-661
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IL-4 and IFN-{gamma} Up-Regulate Substance P Receptor Expression in Murine Peritoneal Macrophages.

I. Marriott and K. L. Bost (2000)
J. Immunol. 165, 182-191
 |  Abstract »  |  Full Text »  |  PDF »

Differential Expression of Neurokinin-1 Receptor by Human Mucosal and Peripheral Lymphoid Cells.

T. Goode, J. O'Connell, W.-Z. Ho, G. C. O'Sullivan, J. K. Collins, S. D. Douglas, and F. Shanahan (2000)
Clin. Vaccine Immunol. 7, 371-376
 |  Abstract »  |  Full Text »  |  PDF »

Respiratory Syncytial Virus Infection and G and/or SH Protein Expression Contribute to Substance P, Which Mediates Inflammation and Enhanced Pulmonary Disease in BALB/c Mice.

R. A. Tripp, D. Moore, J. Winter, and L. J. Anderson (2000)
J. Virol. 74, 1614-1622
 |  Abstract »  |  Full Text »

Genes Upregulated in the Human Trabecular Meshwork in Response to Elevated Intraocular Pressure.

P. Gonzalez, D. L. Epstein, and T. Borrás (2000)
Invest. Ophthalmol. Vis. Sci. 41, 352-361
 |  Abstract »  |  Full Text »

Substance P Activates Coincident NF-AT- and NF-{kappa}B-Dependent Adhesion Molecule Gene Expression in Microvascular Endothelial Cells Through Intracellular Calcium Mobilization.

K. L. Quinlan, S. M. Naik, G. Cannon, C. A. Armstrong, N. W. Bunnett, J. C. Ansel, and S. W. Caughman (1999)
J. Immunol. 163, 5656-5665
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury.

R. A. Gadient and P. H. Patterson (1999)
Stem Cells 17, 127-137
 |  Abstract »  |  Full Text »

Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs.

J Gay, J Fioramonti, R Garcia-Villar, X Emonds-Alt, and L Bueno (1999)
Gut 44, 497-503
 |  Abstract »  |  Full Text »  |  PDF »

VCAM-1 Expression on Human Dermal Microvascular Endothelial Cells Is Directly and Specifically Up-Regulated by Substance P.

K. L. Quinlan, I.-S. Song, S. M. Naik, E. L. Letran, J. E. Olerud, N. W. Bunnett, C. A. Armstrong, S. W. Caughman, and J. C. Ansel (1999)
J. Immunol. 162, 1656-1661
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Mediators of Asthma: An Update.

P. J. Barnes, K. F. Chung, and C. P. Page (1998)
Pharmacol. Rev. 50, 515-596
 |  Abstract »  |  Full Text »  |  PDF »

Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function.

K. L. Quinlan, I.-S. Song, N. W. Bunnett, E. Letran, M. Steinhoff, B. Harten, J. E. Olerud, C. A. Armstrong, S. W. Caughman, and J. C. Ansel (1998)
Am J Physiol Cell Physiol 275, C1580-C1590
 |  Abstract »  |  Full Text »  |  PDF »

Substance P Regulates Somatostatin Expression in Inflammation.

A. M. Blum, D. E. Elliott, A. Metwali, J. Li, K. Qadir, and J. V. Weinstock (1998)
J. Immunol. 161, 6316-6322
 |  Abstract »  |  Full Text »  |  PDF »

Serum Levels of Substance P Are Elevated in Patients With Sickle Cell Disease and Increase Further During Vaso-Occlusive Crisis.

L. A. Michaels, K. Ohene-Frempong, H. Zhao, and S. D. Douglas (1998)
Blood 92, 3148-3151
 |  Abstract »  |  Full Text »  |  PDF »

Association of an insertion polymorphism of angiotensinconverting enzyme gene with the activity of systemic lupus erythematosus.

H Sato, Y Akai, M Iwano, N Kurumatani, H Kurioka, A Kubo, T Yamaguchi, T Fujimoto, and K Dohi (1998)
Lupus 7, 530-534
 |  Abstract »  |  PDF »

Neuropeptides: Mediators of Inflammation and Tissue Repair?.

M. Schaffer, T. Beiter, H. D. Becker, and T. K. Hunt (1998)
Arch Surg 133, 1107-1116
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Substance P (Neurokinin-1) Receptor Is a Marker of Human Mucosal But Not Peripheral Mononulear Cells: Molecular Quantitation and Localization.

T. Goode, J. O'Connell, C. Sternini, P. Anton, H. Wong, G. C. O'Sullivan, J. K. Collins, and F. Shanahan (1998)
J. Immunol. 161, 2232-2240
 |  Abstract »  |  Full Text »  |  PDF »

Tumor necrosis factor induces neuroendocrine differentiation in small cell lung cancer cell lines.

K. J. Haley, K. Patidar, F. Zhang, R. L. Emanuel, and M. E. Sunday (1998)
Am J Physiol Lung Cell Mol Physiol 275, L311-L321
 |  Abstract »  |  Full Text »  |  PDF »

Immunization and Challenge with Toluene Diisocyanate Decrease Tachykinin and Calcitonin Gene-Related Peptide Immunoreactivity in Guinea Pig Central Airways.

C. E. MAPP, R. E. LUCCHINI, D. MIOTTO, P. CHITANO, L. JOVINE, M. SAETTA, P. MAESTRELLI, D. R. SPRINGALL, J. POLAK, and L. M. FABBRI (1998)
Am. J. Respir. Crit. Care Med. 158, 263-269
 |  Abstract »  |  Full Text »  |  PDF »

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W. P. Fehder, W.-Z. Ho, D. E. Campbell, W. W. Tourtellotte, L. Michaels, J. R. Cutilli, M. Uvaydova, and S. D. Douglas (1998)
Clin. Vaccine Immunol. 5, 303-307
 |  Abstract »  |  Full Text »

The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-{alpha} and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor.

M. B. P. Soares, R. G. Titus, C. B. Shoemaker, J. R. David, and M. Bozza (1998)
J. Immunol. 160, 1811-1816
 |  Abstract »  |  Full Text »  |  PDF »

No Neuronal Regulation of Murine Bone Marrow Function.

H. B. Benestad, I. Strom-Gundersen, P. Ole Iversen, E. Haug, and A. Nja (1998)
Blood 91, 1280-1287
 |  Abstract »  |  Full Text »  |  PDF »

Hyperinnervation of the Airways in Transgenic Mice Overexpressing Nerve Growth Factor.

G. W. Hoyle, R. M. Graham, J. B. Finkelstein, K.-P. T. Nguyen, D. Gozal, and M. Friedman (1998)
Am. J. Respir. Cell Mol. Biol. 18, 149-157
 |  Abstract »  |  Full Text »

Rat alveolar macrophages express preprotachykinin gene-I mRNA-encoding tachykinins.

C. R. Killingsworth, S. A. Shore, F. Alessandrini, R. D. Dey, and J. D. Paulauskis (1997)
Am J Physiol Lung Cell Mol Physiol 273, L1073-L1081
 |  Abstract »  |  Full Text »  |  PDF »

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and Vasoactive Intestinal Peptide (VIP) Stimulate Interleukin-6 Production through the Third Subtype of PACAP/VIP Receptor in Rat Bone Marrow-Derived Stromal Cells.

Y. Cai, X. Xin, G.-J. Shim, Y. Mokuno, H. Uehara, T. Yamada, T. Agui, and K. Matsumoto (1997)
Endocrinology 138, 2515-2520
 |  Abstract »  |  Full Text »  |  PDF »

A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei.

P. G. E. Kennedy, J. Rodgers, F. W. Jennings, M. Murray, S. E. Leeman, and J. M. Burke (1997)
PNAS 94, 4167-4170
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous Substance P Mediates Cold Water Stress-Induced Increase in Interleukin-6 Secretion from Peritoneal Macrophages.

G. F. Zhu, C. Chancellor-Freeland, A. S. Berman, R. Kage, S. E. Leeman, D. I. Beller, and P. H. Black (1996)
J. Neurosci. 16, 3745-3752
 |  Abstract »  |  Full Text »  |  PDF »

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