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Science 9 September 1988:
Vol. 241. no. 4871, pp. 1349 - 1352
DOI: 10.1126/science.2457952
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Articles
Science, Vol 241, Issue 4871, 1349-1352
Copyright © 1988 by American Association for the Advancement of Science
Site-directed neovessel formation in vivo
JA Thompson,
KD Anderson,
JM DiPietro,
JA Zwiebel,
M Zametta,
WF Anderson,
and
T Maciag
Laboratory of Molecular Hematology, National Heart, Lung and Blood Institute, Bethesda, MD 20892.
Angiogenesis is an important component of organogenesis and wound repair and occurs during the pathology of oncogenesis, atherogenesis, and other disease processes. Thus, it is important to understand the physiological mechanisms that control neovascularization, especially with methods that permit the molecular dissection of the phenomenon in vivo. Heparin-binding growth factor-1 was shown to bind to collagen type I and type IV. When complexed with gelatin, heparin-binding growth factor-1 can induce neovascularization at polypeptide concentrations that are consistent with the biological activity of the mitogen in vitro. The adsorption strategy induces rapid blood vessel formation at and between organ- and tissue-specific sites and permits recovery of the site-specific implant for examination and manipulation by molecular methods.
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