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Science 30 September 1988:
Vol. 241. no. 4874, pp. 1815 - 1817
DOI: 10.1126/science.3051377
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Articles

Science, Vol 241, Issue 4874, 1815-1817
Copyright © 1988 by American Association for the Advancement of Science

articles

Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life

FH Claas, Y Gijbels, J van der Velden-de Munck, and JJ van Rood

Department of Immunohaematology, University Hospital, Leiden, the Netherlands.

Patients who have received many transfusions become highly sensitized and develop antibodies against almost all HLA alloantigens, so that finding a cross-match negative kidney donor is difficult. A survey of those patients showed that 50 percent did not form antibodies against the noninherited maternal HLA antigens. Apart from the obvious clinical implications, the data indicate that a human equivalent of murine neonatal or actively acquired tolerance has now been identified.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero.
J. E. Mold, J. Michaelsson, T. D. Burt, M. O. Muench, K. P. Beckerman, M. P. Busch, T.-H. Lee, D. F. Nixon, and J. M. McCune (2008)
Science 322, 1562-1565
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Protection against rheumatoid arthritis by HLA: nature and nurture.
A L Feitsma, A H M van der Helm-van Mil, T W J Huizinga, R R P de Vries, and R E M Toes (2008)
Ann Rheum Dis 67, iii61-iii63
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Heredity--Venturing Beyond Genetics.
M.-C. Maurel and C. Kanellopoulos-Langevin (2008)
Biol Reprod 79, 2-8
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Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development.
A. L. Feitsma, J. Worthington, A. H. M. van der Helm-van Mil, D. Plant, W. Thomson, J. Ursum, D. van Schaardenburg, I. E. van der Horst-Bruinsma, J. J. van Rood, T. W. J. Huizinga, et al. (2007)
PNAS 104, 19966-19970
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Developmental Exposure to Noninherited Maternal Antigens Induces CD4+ T Regulatory Cells: Relevance to Mechanism of Heart Allograft Tolerance.
M. L. Molitor-Dart, J. Andrassy, J. Kwun, H. A. Kayaoglu, D. A. Roenneburg, L. D. Haynes, J. R. Torrealba, J. L. Bobadilla, H. W. Sollinger, S. J. Knechtle, et al. (2007)
J. Immunol. 179, 6749-6761
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Influence of Maternal-Fetal Histocompatibility and MHC Zygosity on Maternal Microchimerism.
J. Kaplan and S. Land (2005)
J. Immunol. 174, 7123-7128
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Affinity-Dependent Alterations of Mouse B Cell Development by Noninherited Maternal Antigen.
C. Vernochet, S. M. Caucheteux, M.-C. Gendron, J. Wantyghem, and C. Kanellopoulos-Langevin (2005)
Biol Reprod 72, 460-469
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Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism.
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Blood 104, 3821-3828
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T lymphocytes of recipient origin may contribute to the recovery of specific immune response toward viruses and fungi in children undergoing cord blood transplantation.
D. Montagna, F. Locatelli, A. Moretta, D. Lisini, C. Previdere, P. Grignani, P. DeStefano, G. Giorgiani, E. Montini, S. Pagani, et al. (2004)
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Tolerance to Noninherited Maternal MHC Antigens in Mice.
J. Andrassy, S. Kusaka, E. Jankowska-Gan, J. R. Torrealba, L. D. Haynes, B. R. Marthaler, R. C. Tam, B. M.-W. Illigens, N. Anosova, G. Benichou, et al. (2003)
J. Immunol. 171, 5554-5561
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Non-inherited maternal HLA alleles are associated with rheumatoid arthritis.
S. Harney, J. Newton, A. Milicic, M. A. Brown, and B. P. Wordsworth (2003)
Rheumatology 42, 171-174
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Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling.
J. J. van Rood, F. R. Loberiza Jr, M.-J. Zhang, M. Oudshoorn, F. Claas, M. S. Cairo, R. E. Champlin, R. P. Gale, O. Ringden, J. M. Hows, et al. (2002)
Blood 99, 1572-1577
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Persistent maternally derived peripheral microchimerism is associated with the juvenile idiopathic inflammatory myopathies.
C. M. Artlett, F. W. Miller, and L. G. Rider (2001)
Rheumatology 40, 1279-1284
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Quantitative Analysis of the Bidirectional Fetomaternal Transfer of Nucleated Cells and Plasma DNA.
Y.M. D. Lo, T. K. Lau, L. Y.S. Chan, T. N. Leung, and A. M.Z. Chang (2000)
Clin. Chem. 46, 1301-1309
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Systemic Sclerosis: New Insights in Autoimmunity.
S. E. J. Kaal, F. H. J. Van den Hoogen, E. M. G. J. De Jong, and H. E. Viëtor (1999)
Experimental Biology and Medicine 222, 1-8
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Non-host cells in the pathogenesis of autoimmune disease: a new paradigm?.
J L. NELSON (1999)
Ann Rheum Dis 58, 518-520
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Genomic Imbalances Associated with Acquired Resistance to Platinum Analogues.
B. Leyland-Jones, L. R. Kelland, K. R. Harrap, and L. R. Hiorns (1999)
Am. J. Pathol. 155, 77-84
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HLA (A*0201) Mimicry by Anti-Idiotypic Monoclonal Antibodies.
W. J. Burlingham, E. Jankowska-Gan, L. DeVito-Haynes, J. H. Fechner Jr., K. T. Hogan, F. H. J. Claas, A. Mulder, X. Wang, and S. Ferrone (1998)
J. Immunol. 161, 6705-6714
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The Effect of Tolerance to Noninherited Maternal HLA Antigens on the Survival of Renal Transplants from Sibling Donors.
W. J. Burlingham, A. P. Grailer, D. M. Heisey, F. H.J. Claas, D. Norman, T. Mohanakumar, D. C. Brennan, H. de Fijter, T. van Gelder, J. D. Pirsch, et al. (1998)
N. Engl. J. Med. 339, 1657-1664
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Influence of non-inherited maternal HLA-DR antigens on susceptibility to rheumatoid arthritis.
I E van der Horst-Bruinsma, J M W Hazes, G M T. Schreuder, T R D J Radstake, P Barrera, L B A van de Putte, D Mustamu, D van Schaardenburg, F C Breedveld, and R R P de Vries (1998)
Ann Rheum Dis 57, 672-675
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The influence of allogeneic cells on the human T and B cell repertoire.
J. van Rood and F. Claas (1990)
Science 248, 1388-1393
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