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Science 30 September 1988:
Vol. 241. no. 4874, pp. 1826 - 1828
DOI: 10.1126/science.3175625
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Articles

Science, Vol 241, Issue 4874, 1826-1828
Copyright © 1988 by American Association for the Advancement of Science

articles

Influences of dietary sodium on functional taste receptor development: a sensitive period

DL Hill and PR Przekop Jr

Department of Psychology, University of Virginia, Charlottesville 22903.

Restriction of maternal dietary sodium on or before embryonic day 8 reduced taste responses of the chorda tympani nerve to sodium chloride in the offspring. The response attenuation was substantial; responses to sodium chloride in the offspring of deprived rats were approximately 40 percent of those in control animals. Instituting the low sodium diet at embryonic day 10 or later did not produce functional changes. Thus, a sensitive period for the gustatory system exists, and the abrupt transition from maximal environmental susceptibility to no susceptibility occurs during a 2-day prenatal period. Moreover, events important in determining the developmental fate of taste membrane components occur before the initial formation of taste buds.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Extensive Reorganization of Primary Afferent Projections into the Gustatory Brainstem Induced by Feeding a Sodium-Restricted Diet during Development: Less Is More.
J. E. Mangold and D. L. Hill (2007)
J. Neurosci. 27, 4650-4662
   Abstract »    Full Text »    PDF »
Prenatal and early postnatal dietary sodium restriction sensitizes the adult rat to amphetamines.
S. M. McBride, B. Culver, and F. W. Flynn (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R1192-R1199
   Abstract »    Full Text »    PDF »
Sensitive periods for the effect of dietary sodium restriction on intact and denervated taste receptor cells.
L. P. McCluskey and D. L. Hill (2002)
Am J Physiol Regulatory Integrative Comp Physiol 283, R1275-R1284
   Abstract »    Full Text »    PDF »
Dietary NaCl Influences the Organization of Chorda Tympani Neurons Projecting to the Nucleus of the Solitary Tract in Rats.
D. W. Pittman and R. J. Contreras (2002)
Chem Senses 27, 333-341
   Abstract »    Full Text »    PDF »
Lack of Functional and Morphological Susceptibility of the Greater Superficial Petrosal Nerve to Developmental Dietary Sodium Restriction.
S. I. Sollars and D. L. Hill (2000)
Chem Senses 25, 719-727
   Abstract »    Full Text »    PDF »


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