Science 7 October 1988: Vol. 242. no. 4875, pp. 50 - 61 DOI: 10.1126/science.2459775

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Articles

Molecular Dynamics Simulation of Kv Channel Voltage Sensor Helix in a Lipid Membrane with Applied Electric Field.

M. Nishizawa and K. Nishizawa (2008)
Biophys. J. 95, 1729-1744
 |  Abstract »  |  Full Text »  |  PDF »

Nav1.4 Deregulation in Dystrophic Skeletal Muscle Leads to Na+ Overload and Enhanced Cell Death.

C. Hirn, G. Shapovalov, O. Petermann, E. Roulet, and U. T. Ruegg (2008)
J. Gen. Physiol. 132, 199-208
 |  Abstract »  |  Full Text »  |  PDF »

KCNE Peptides Differently Affect Voltage Sensor Equilibrium and Equilibration Rates in KCNQ1 K+ Channels.

J. M. Rocheleau and W. R. Kobertz (2007)
J. Gen. Physiol. 131, 59-68
 |  Abstract »  |  Full Text »  |  PDF »

Neuroecology, Chemical Defense, and the Keystone Species Concept.

R. K. Zimmer and R. P. Ferrer (2007)
Biol. Bull. 213, 208-225
 |  Abstract »  |  Full Text »  |  PDF »

Dynamics of the Kv1.2 Voltage-Gated K+ Channel in a Membrane Environment.

V. Jogini and B. Roux (2007)
Biophys. J. 93, 3070-3082
 |  Abstract »  |  Full Text »  |  PDF »

Psychostimulants, L-type Calcium Channels, Kinases, and Phosphatases.

A. M. Rajadhyaksha and B. E. Kosofsky (2005)
Neuroscientist 11, 494-502
 |  Abstract »  |  PDF »

Calcium Absorption Across Epithelia.

J. G. J. Hoenderop, B. Nilius, and R. J. M. Bindels (2005)
Physiol Rev 85, 373-422
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Sodium-Calcium Exchange Inhibitors, KB-R7943 and SEA0400, on Aconitine-Induced Arrhythmias in Guinea Pigs in Vivo, in Vitro, and in Computer Simulation Studies.

Md. S. Amran, K. Hashimoto, and N. Homma (2004)
J. Pharmacol. Exp. Ther. 310, 83-89
 |  Abstract »  |  Full Text »  |  PDF »

Electrostatic Model of S4 Motion in Voltage-Gated Ion Channels.

H. Lecar, H. P. Larsson, and M. Grabe (2003)
Biophys. J. 85, 2854-2864
 |  Abstract »  |  Full Text »  |  PDF »

Noise and stochastic resonance in voltage-gated ion channels.

R. K. Adair (2003)
PNAS 100, 12099-12104
 |  Abstract »  |  Full Text »  |  PDF »

Novel Interactions Identified between {micro}-Conotoxin and the Na+ Channel Domain I P-loop: Implications for Toxin-Pore Binding Geometry.

T. Xue, I. L. Ennis, K. Sato, R. J. French, and R. A. Li (2003)
Biophys. J. 85, 2299-2310
 |  Abstract »  |  Full Text »  |  PDF »

Potential of mean force calculations on an L-type calcium channel model.

G. Barreiro, C. R. W. Guimaraes, and R. B. de Alencastro (2003)
Protein Eng. Des. Sel. 16, 209-215
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement of closed-state inactivation in long QT syndrome sodium channel mutation Delta KPQ.

T. Chen and M. F. Sheets (2002)
Am J Physiol Heart Circ Physiol 283, H966-H975
 |  Abstract »  |  Full Text »  |  PDF »

A molecular dynamics study of an L-type calcium channel model.

G. Barreiro, C. R. W. Guimaraes, and R. B. de Alencastro (2002)
Protein Eng. Des. Sel. 15, 109-122
 |  Abstract »  |  Full Text »  |  PDF »

Calcium channels - basic aspects of their structure, function and gene encoding; anesthetic action on the channels - a review: [Revue : notions de base sur la structure, la fonction et l'encodage genetique des canaux calciques et action des anesthesiques sur ces canaux].

M. Yamakage and A. Namiki (2002)
Can J Anesth 49, 151-164
 |  Abstract »  |  Full Text »  |  PDF »

Structural analysis of free and enzyme-bound amaranth {alpha}-amylase inhibitor: classification within the knottin fold superfamily and analysis of its functional flexibility.

O. Carugo, S. Lu, J. Luo, X. Gu, S. Liang, S. Strobl, and S. Pongor (2001)
Protein Eng. Des. Sel. 14, 639-646
 |  Abstract »  |  Full Text »  |  PDF »

A new mutation in a family with cold-aggravated myotonia disrupts Na+ channel inactivation.

F.-F. Wu, M.P. Takahashi, E. Pegoraro, C. Angelini, P. Colleselli, S.C. Cannon, and E.P. Hoffman (2001)
Neurology 56, 878-884
 |  Abstract »  |  Full Text »  |  PDF »

Glucocorticoids Regulate Plasma Membrane Potential During Rat Thymocyte Apoptosis in Vivo and in Vitro.

C. L. Mann and J. A. Cidlowski (2001)
Endocrinology 142, 421-429
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Organic Antagonists of Ca2+, Na+, and K+ on Chemotaxis and Motility of Escherichia coli.

L. S. Tisa, J. J. Sekelsky, and J. Adler (2000)
J. Bacteriol. 182, 4856-4861
 |  Abstract »  |  Full Text »

Mutational Analysis of Basic Residues in the Rat Vesicular Acetylcholine Transporter. IDENTIFICATION OF A TRANSMEMBRANE ION PAIR AND EVIDENCE THAT HISTIDINE IS NOT INVOLVED IN PROTON TRANSLOCATION.

M.-H. Kim, M. Lu, M. Kelly, and L. B. Hersh (2000)
J. Biol. Chem. 275, 6175-6180
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac Na+ Channel Dysfunction in Brugada Syndrome Is Aggravated by {beta}1-Subunit.

N. Makita, N. Shirai, D. W. Wang, K. Sasaki, A. L. George Jr, M. Kanno, and A. Kitabatake (2000)
Circulation 101, 54-60
 |  Abstract »  |  Full Text »  |  PDF »

Arg-52 in the Melibiose Carrier of Escherichia coli Is Important for Cation-Coupled Sugar Transport and Participates in an Intrahelical Salt Bridge.

P. J. Franco and T. H. Wilson (1999)
J. Bacteriol. 181, 6377-6386
 |  Abstract »  |  Full Text »

Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current.

D. Gebremedhin, A. R. Lange, W. B. Campbell, C. J. Hillard, and D. R. Harder (1999)
Am J Physiol Heart Circ Physiol 276, H2085-H2093
 |  Abstract »  |  Full Text »  |  PDF »

AT-AC Pre-mRNA Splicing Mechanisms and Conservation of Minor Introns in Voltage-Gated Ion Channel Genes.

Q. Wu and A. R. Krainer (1999)
Mol. Cell. Biol. 19, 3225-3236
 |  Full Text »  |  PDF »

Identification of structural elements of the testis-specific voltage dependent calcium channel that potentially regulate its biophysical properties.

L. O. Goodwin, N. B. Leeds, D. Guzowski, I. R. Hurley, R. G. Pergolizzi, and S. Benoff (1999)
Mol. Hum. Reprod. 5, 311-322
 |  Abstract »  |  Full Text »  |  PDF »

Structure-Activity Relationships of the Kvbeta 1 Inactivation Domain and Its Putative Receptor Probed Using Peptide Analogs of Voltage-gated Potassium Channel alpha - and beta -Subunits.

S. J. Lombardi, A. Truong, P. Spence, K. J. Rhodes, and P. G. Jones (1998)
J. Biol. Chem. 273, 30092-30096
 |  Abstract »  |  Full Text »  |  PDF »

Synergism between toxin-gamma from Brazilian scorpion Tityus serrulatus and veratridine in chromaffin cells.

I. M. Conceicao, I. Lebrun, M. Cano-Abad, L. Gandia, J. M. Hernandez-Guijo, M. G. Lopez, M. Villarroya, A. Jurkiewicz, and A. G. Garcia (1998)
Am J Physiol Cell Physiol 274, C1745-C1754
 |  Abstract »  |  Full Text »  |  PDF »

The Membrane Topology of Human Transient Receptor Potential 3 as Inferred from Glycosylation-scanning Mutagenesis and Epitope Immunocytochemistry.

B. Vannier, X. Zhu, D. Brown, and L. Birnbaumer (1998)
J. Biol. Chem. 273, 8675-8679
 |  Abstract »  |  Full Text »  |  PDF »

Genetic and Developmental Characterization of Dmca1D, a Calcium Channel {alpha}1 Subunit Gene in Drosophila melanogaster.

D. F. Eberl, D. Ren, G. Feng, L. J. Lorenz, D. Van Vactor, and L. M. Hall (1998)
Genetics 148, 1159-1169
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Polymorphism in MDR-1: A Tool for Examining Allelic Expression in Normal Cells, Unselected and Drug-Selected Cell Lines, and Human Tumors.

L. A. Mickley, J.-S. Lee, Z. Weng, Z. Zhan, M. Alvarez, W. Wilson, S. E. Bates, and T. Fojo (1998)
Blood 91, 1749-1756
 |  Abstract »  |  Full Text »  |  PDF »

A Critical Role for the S4-S5 Intracellular Loop in Domain IV of the Sodium Channel alpha -Subunit in Fast Inactivation.

J. C. McPhee, D. S. Ragsdale, T. Scheuer, and W. A. Catterall (1998)
J. Biol. Chem. 273, 1121-1129
 |  Abstract »  |  Full Text »  |  PDF »

Arabidopsis NPH1: A Protein Kinase with a Putative Redox-Sensing Domain.

E. Huala, P. W. Oeller, E. Liscum, I. Han, E. Larsen, and W. R. Briggs (1997)
Science 278, 2120-2123
 |  Abstract »  |  Full Text »

Molecular Studies on the Voltage Dependence of Dihydropyridine Action on L-type Ca2+ Channels. CRITICAL INVOLVEMENT OF TYROSINE RESIDUES IN MOTIF IIIS6 AND IVS6.

I. Bodi, H. Yamaguchi, M. Hara, M. He, A. Schwartz, and G. Varadi (1997)
J. Biol. Chem. 272, 24952-24960
 |  Abstract »  |  Full Text »  |  PDF »

Parathyroid hormone stimulates calcium influx and the cAMP messenger system in rat enterocytes.

G. Picotto, V. Massheimer, and R. Boland (1997)
Am J Physiol Cell Physiol 273, C1349-C1353
 |  Abstract »  |  Full Text »  |  PDF »

Alternative Splicing of the Sodium Channel SCN8A Predicts a Truncated Two-domain Protein in Fetal Brain and Non-neuronal Cells.

N. W. Plummer, M. W. McBurney, and M. H. Meisler (1997)
J. Biol. Chem. 272, 24008-24015
 |  Abstract »  |  Full Text »  |  PDF »

Body-Surface Distribution of Changes in Activation-Recovery Intervals Before and After Catheter Ablation in Patients With Wolff-Parkinson-White Syndrome : Clinical Evidence for Ventricular `Electrical Remodeling' With Prolongation of Action-Potential Duration Over a Preexcited Area.

M. Akahoshi, M. Hirai, Y. Inden, H. Sano, A. Shimizu, T. Kondo, M. Makino, M. Horiba, Y. Yoshida, N. Tsuboi, et al. (1997)
Circulation 96, 1566-1574
 |  Abstract »  |  Full Text »

Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells.

E. V.-S. de Miera, B. Rudy, M. Sugimori, and R. Llinas (1997)
PNAS 94, 7059-7064
 |  Abstract »  |  Full Text »  |  PDF »

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X. Zhang, J. W. Anderson, and D. Fedida (1997)
J. Pharmacol. Exp. Ther. 281, 1247-1256
 |  Abstract »  |  Full Text »

Ion Channels -- Basic Science and Clinical Disease.

M. J. Ackerman and D. E. Clapham (1997)
N. Engl. J. Med. 336, 1575-1586
 |  Full Text »  |  PDF »

Kvbeta 2 Inhibits the Kvbeta 1-mediated Inactivation of K+ Channels in Transfected Mammalian Cells.

J. Xu and M. Li (1997)
J. Biol. Chem. 272, 11728-11735
 |  Abstract »  |  Full Text »  |  PDF »

An Antisense Oligonucleotide on the Mouse Shaker-like Potassium Channel Kv1.1 Gene Prevents Antinociception Induced by Morphine and Baclofen.

N. Galeotti, C. Ghelardini, L. Papucci, S. Capaccioli, A. Quattrone, and A. Bartolini (1997)
J. Pharmacol. Exp. Ther. 281, 941-949
 |  Abstract »  |  Full Text »

Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes.

Y.-F. Xiao, A. M. Gomez, J. P. Morgan, W. J. Lederer, and A. Leaf (1997)
PNAS 94, 4182-4187
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Sodium and Calcium Channel Blockade on Cytosolic Calcium Oscillations and Phasic Contractions of Myometrial Tissue.

M. Phillippe and A. Basa (1997)
Reproductive Sciences 4, 72-77
 |  Abstract »  |  PDF »

{blacksquare} REVIEW : Ionic Channels with Weak Voltage-dependence.

M. A. Rizzo (1997)
Neuroscientist 3, 102-111
 |  Abstract »  |  PDF »

Molecular Cloning and Functional Reconstitution of a Urate Transporter/Channel.

E. Leal-Pinto, W. Tao, J. Rappaport, M. Richardson, B. A. Knorr, and R. G. Abramson (1997)
J. Biol. Chem. 272, 617-625
 |  Abstract »  |  Full Text »  |  PDF »

Down-regulation of L-type Ca2+ Channel Transcript Levels by 1,25-Dihyroxyvitamin D3. OSTEOBLASTIC CELLS EXPRESS L-TYPE alpha 1C Ca2+ CHANNEL ISOFORMS.

J. G. Meszaros, N. J. Karin, K. Akanbi, and M. C. Farach-Carson (1996)
J. Biol. Chem. 271, 32981-32985
 |  Abstract »  |  Full Text »  |  PDF »

Absence of the beta  subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling.

R. G. Gregg, A. Messing, C. Strube, M. Beurg, R. Moss, M. Behan, M. Sukhareva, S. Haynes, J. A. Powell, R. Coronado, et al. (1996)
PNAS 93, 13961-13966
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Determinants of beta 1 Subunit-Induced Gating Modulation in Voltage-Dependent Na+ Channels.

N. Makita, P. B. Bennett, and A. L. George Jr. (1996)
J. Neurosci. 16, 7117-7127
 |  Abstract »  |  Full Text »  |  PDF »

Antiarrhythmic Effects of Polyunsaturated Fatty Acids: Recent Studies.

J. X. Kang and A. Leaf (1996)
Circulation 94, 1774-1780
 |  Full Text »

Vesicular Monoamine Transport Inhibitors: Novel Action at Calcium Channels to Prevent Catecholamine Secretion.

M. Mahata, S. K. Mahata, R. J. Parmer, and D. T. O'Connor (1996)
Hypertension 28, 414-420
 |  Abstract »  |  Full Text »

Expression of Kv1.1 Delayed Rectifier Potassium Channels in Lec Mutant Chinese Hamster Ovary Cell Lines Reveals a Role for Sialidation in Channel Function.

W. B. Thornhill, M. B. Wu, X. Jiang, X. Wu, P. T. Morgan, and J. F. Margiotta (1996)
J. Biol. Chem. 271, 19093-19098
 |  Abstract »  |  Full Text »  |  PDF »

Camstatins Are Peptide Antagonists of Calmodulin Based Upon a Conserved Structural Motif in PEP-19, Neurogranin, and Neuromodulin.

J. R. Slemmon, J. I. Morgan, S. M. Fullerton, W. Danho, B. S. Hilbush, and T. M. Wengenack (1996)
J. Biol. Chem. 271, 15911-15917
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of the ATP-sensitive, Inwardly Rectifying K[IMAGE] Channel, ROMK, by Cyclic AMP-dependent Protein Kinase.

Z.-C. Xu, Y. Yang, and S. C. Hebert (1996)
J. Biol. Chem. 271, 9313-9319
 |  Abstract »  |  Full Text »  |  PDF »

Leucine 18, a Hydrophobic Residue Essential for High Affinity Binding of Anthopleurin B to the Voltage-sensitive Sodium Channel.

B. L. Dias-Kadambi, C. L. Drum, D. A. Hanck, and K. M. Blumenthal (1996)
J. Biol. Chem. 271, 9422-9428
 |  Abstract »  |  Full Text »  |  PDF »

Immunochemical Identification and Differential Phosphorylation of Alternatively Spliced Forms of the alpha[IMAGE] Subunit of Brain Calcium Channels.

T. Sakurai, J. W. Hell, A. Woppmann, G. P. Miljanich, and W. A. Catterall (1995)
J. Biol. Chem. 270, 21234-21242
 |  Abstract »  |  Full Text »  |  PDF »

On the Molecular Nature of the Lidocaine Receptor of Cardiac Na+ Channels : Modification of Block by Alterations in the {alpha}-Subunit III-IV Interdomain.

P. B. Bennett, C. Valenzuela, L.-Q. Chen, and R. G. Kallen (1995)
Circ. Res. 77, 584-592
 |  Abstract »  |  Full Text »

Role of Potassium Channels in Cerebral Blood Vessels.

T. Kitazono, F. M. Faraci, H. Taguchi, and D. D. Heistad (1995)
Stroke 26, 1713-1723
 |  Abstract »  |  Full Text »

Phosphorylation Modulates the Function of the Calcium Release Channel of Sarcoplasmic Reticulum from Cardiac Muscle.

Jür. Hain, H. Onoue, M. Mayrleitner, S. Fleischer, and H. Schindler (1995)
J. Biol. Chem. 270, 2074-2081
 |  Abstract »  |  Full Text »  |  PDF »

Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase.

M Li, J. West, R Numann, B. Murphy, T Scheuer, and W. Catterall (1993)
Science 261, 1439-1442
 |  Abstract »  |  PDF »

Cardiac Ion Channels.

A. M. Katz (1993)
N. Engl. J. Med. 328, 1244-1251
 |  Full Text »

Molecular localization of an ion-binding site within the pore of mammalian sodium channels.

P. Backx, D. Yue, J. Lawrence, E Marban, and G. Tomaselli (1992)
Science 257, 248-251
 |  Abstract »  |  PDF »

An amino acid mutation in a potassium channel that prevents inhibition by protein kinase C.

A. Busch, M. Varnum, R. North, and J. Adelman (1992)
Science 255, 1705-1707
 |  Abstract »  |  PDF »

The roles of the subunits in the function of the calcium channel.

D Singer, M Biel, I Lotan, V Flockerzi, F Hofmann, and N Dascal (1991)
Science 253, 1553-1557
 |  Abstract »  |  PDF »

A component of calcium-activated potassium channels encoded by the Drosophila slo locus.

N. Atkinson, G. Robertson, and B Ganetzky (1991)
Science 253, 551-555
 |  Abstract »  |  PDF »

A distinct potassium channel polypeptide encoded by the Drosophila eag locus.

J Warmke, R Drysdale, and B Ganetzky (1991)
Science 252, 1560-1562
 |  Abstract »  |  PDF »

Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel.

G Yellen, M. Jurman, T Abramson, and R MacKinnon (1991)
Science 251, 939-942
 |  Abstract »  |  PDF »

Exchange of conduction pathways between two related K+ channels.

H. Hartmann, G. Kirsch, J. Drewe, M Taglialatela, R. Joho, and A. Brown (1991)
Science 251, 942-944
 |  Abstract »  |  PDF »

Hyperkalemic periodic paralysis and the adult muscle sodium channel alpha-subunit gene.

B Fontaine, T. Khurana, E. Hoffman, G. Bruns, J. Haines, J. Trofatter, M. Hanson, J Rich, H McFarlane, D. Yasek, et al. (1990)
Science 250, 1000-1002
 |  Abstract »  |  PDF »

Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels.

R MacKinnon and G Yellen (1990)
Science 250, 276-279
 |  Abstract »  |  PDF »

Molecular structure of charybdotoxin, a pore-directed inhibitor of potassium ion channels.

W Massefski Jr, A. Redfield, D. Hare, and C Miller (1990)
Science 249, 521-524
 |  Abstract »  |  PDF »

Atrionatriuretic peptide transforms cardiac sodium channels into calcium-conducting channels.

L. Sorbera and M Morad (1990)
Science 247, 969-973
 |  Abstract »  |  PDF »

Functional properties of rat brain sodium channels expressed in a somatic cell line.

T Scheuer, V. Auld, S Boyd, J Offord, R Dunn, and W. Catterall (1990)
Science 247, 854-858
 |  Abstract »  |  PDF »

Fish as model systems.

D. Powers (1989)
Science 246, 352-358
 |  Abstract »  |  PDF »

Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor.

R MacKinnon and C Miller (1989)
Science 245, 1382-1385
 |  Abstract »  |  PDF »

Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle.

P Ruth, A Rohrkasten, M Biel, E Bosse, S Regulla, H. Meyer, V Flockerzi, and F Hofmann (1989)
Science 245, 1115-1118
 |  Abstract »  |  PDF »

Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways.

B Schubert, A. VanDongen, G. Kirsch, and A. Brown (1989)
Science 245, 516-519
 |  Abstract »  |  PDF »

Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure.

J Krupinski, F Coussen, H. Bakalyar, W. Tang, P. Feinstein, K Orth, C Slaughter, R. Reed, and A. Gilman (1989)
Science 244, 1558-1564
 |  Abstract »  |  PDF »

Clockwise Domain Arrangement of the Sodium Channel Revealed by {micro}-Conotoxin (GIIIA) Docking Orientation.

R. A. Li, I. L. Ennis, R. J. French, S. C. Dudley Jr., G. F. Tomaselli, and E. Marban (2001)
J. Biol. Chem. 276, 11072-11077
 |  Abstract »  |  Full Text »  |  PDF »

Novel Structural Determinants of {micro}-Conotoxin (GIIIB) Block in Rat Skeletal Muscle ({micro}1) Na+ Channels.

R. A. Li, I. L. Ennis, P. Velez, G. F. Tomaselli, and E. Marban (2000)
J. Biol. Chem. 275, 27551-27558
 |  Abstract »  |  Full Text »  |  PDF »

Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.

T. Zimmer, C. Bollensdorff, V. Haufe, E. Birch-Hirschfeld, and K. Benndorf (2002)
Am J Physiol Heart Circ Physiol 282, H1007-H1017
 |  Abstract »  |  Full Text »  |  PDF »

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