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Science 7 October 1988:
Vol. 242. no. 4875, pp. 99 - 102
DOI: 10.1126/science.2459777
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Articles

Science, Vol 242, Issue 4875, 99-102
Copyright © 1988 by American Association for the Advancement of Science

articles

Ryanodine receptor of skeletal muscle is a gap junction-type channel

J Ma, M Fill, CM Knudson, KP Campbell, and R Coronado

Department of Physiology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030.

In the sarcoplasmic reticulum membrane of skeletal muscle, the ryanodine receptor forms an aqueous pore identified as the calcium-release pathway that operates during excitation-contraction coupling. The purified ryanodine receptor channel has now been shown to have four properties usually associated with gap junction channels: (i) a large nonspecific voltage-dependent conductance consisting of several open states; (ii) an inhibition of open probability by low pH; (iii) an inhibition of open probability by calcium; and (iv) a sensitivity to blockade by heptanol and octanol but not other alcohols. This functional homology may provide an insight into the mechanism of how muscle cells transduce depolarization into an intracellular release of calcium.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)