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Science 28 October 1988:
Vol. 242. no. 4878, pp. 583 - 585
DOI: 10.1126/science.2845584
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Articles

Science, Vol 242, Issue 4878, 583-585
Copyright © 1988 by American Association for the Advancement of Science

articles

Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated

JW Funder, PT Pearce, R Smith, and AI Smith

Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia.

Mineralocorticoid receptors, both when in tissue extracts and when recombinant-derived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. In mineralocorticoid target tissues the receptors are selective for aldosterone in vivo because of the presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs. These analogs cannot bind to mineralocorticoid receptors.


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Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression.
M. Liang, B. Yuan, E. Rute, A. S. Greene, M. Olivier, and A. W. Cowley Jr. (2003)
Physiol Genomics 12, 229-237
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Role of Local 11{beta}-Hydroxysteroid Dehydrogenase Type 2 Expression in Determining the Phenotype of Adrenal Adenomas.
T. Mune, H. Morita, T. Suzuki, Y. Takahashi, Y. Isomura, T. Tanahashi, H. Daido, N. Yamakita, T. Deguchi, H. Sasano, et al. (2003)
J. Clin. Endocrinol. Metab. 88, 864-870
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The Severe Form of Hypertension Caused by the Activating S810L Mutation in the Mineralocorticoid Receptor Is Cortisone Related.
M.-E. Rafestin-Oblin, A. Souque, B. Bocchi, G. Pinon, J. Fagart, and A. Vandewalle (2003)
Endocrinology 144, 528-533
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Hypokalaemia and paralysis.
S.-H. LIN, M.R. DAVIDS, and M.L. HALPERIN (2003)
QJM 96, 161-169
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