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Science 4 November 1988:
Vol. 242. no. 4879, pp. 700 - 708
DOI: 10.1126/science.3187519
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Articles

Science, Vol 242, Issue 4879, 700-708
Copyright © 1988 by American Association for the Advancement of Science

articles

Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily

AL Harrelson and CS Goodman

Howard Hughes Medical Institute, University of California, Berkeley 94720.

The cellular cues that guide neuronal growth cones toward their targets are highly conserved in such diverse organisms as insects and vertebrates. Evidence presented here suggests that the molecular mechanisms underlying these events may be equally conserved. This article describes the structure and function of fasciclin II, a glycoprotein expressed on a subset of fasciculating axons in the grasshopper embryo. Antibody perturbation experiments suggest that fasciclin II functions in mediating one form of neuronal recognition: selective fasciculation. Fasciclin II is a member of the immunoglobulin gene superfamily and is homologous in structure and function to the neural cell adhesion molecule N-CAM and to several other vertebrate cell adhesion molecules.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)