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Science 4 November 1988:
Vol. 242. no. 4879, pp. 724 - 728
DOI: 10.1126/science.2903551
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Articles

Science, Vol 242, Issue 4879, 724-728
Copyright © 1988 by American Association for the Advancement of Science

articles

Long-term synaptic potentiation

TH Brown, PF Chapman, EW Kairiss, and CL Keenan

Department of Psychology, Yale University, New Haven, CT 06520.

Long-term synaptic potentiation (LTP) is a leading candidate for a synaptic mechanism of rapid learning in mammals. LTP is a persistent increase in synaptic efficacy that can be quickly induced. The biophysical process that controls one type of LTP is formally similar to a synaptic memory mechanism postulated decades ago by the psychologist Donald Hebb. A key aspect of the modification process involves the N-methyl-D-aspartate (NMDA) receptor-ionophore complex. This ionophore allows calcium influx only if the endogenous ligand glutamate binds to the NMDA receptor and if the voltage across the associated channel is also sufficiently depolarized to relieve a magnesium block. According to one popular hypothesis, the resulting increase in the intracellular calcium concentration activates protein kinases that enhance the postsynaptic conductance. Further biophysical and molecular understanding of the modification process should facilitate detailed explorations of the mnemonic functions of LTP.


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