Related Content
Search Google Scholar for:
|
|
Science 4 November 1988:
Vol. 242. no. 4879, pp. 728 - 735
DOI: 10.1126/science.3055293
|
|
Articles
Science, Vol 242, Issue 4879, 728-735
Copyright © 1988 by American Association for the Advancement of Science
The neural basis for learning of simple motor skills
SG Lisberger
Department of Physiology, University of California, San Francisco 94143.
The vestibulo-ocular reflex (VOR) is a simple movement that has been used to investigate the neural basis for motor learning in monkeys. The function of the VOR is to stabilize retinal images by generating smooth eye movements that are equal and opposite to each head movement. Learning occurs whenever image motion occurs persistently during head turns; as a result image stability is gradually restored. A hypothesis is proposed in which the output from the cerebellar cortex of the flocculus guides learning; the locus of learning is in the brain stem, in VOR pathways that are under inhibitory control from the flocculus. Other, parallel VOR pathways do not receive inputs from the flocculus and are not subject to learning. Similarities among the VOR and other motor systems suggest some organizing principles that may apply in many forms of motor learning.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Precerebellar Hindbrain Neurons Encoding Eye Velocity During Vestibular and Optokinetic Behavior in the Goldfish.
- J. C. Beck, P. Rothnie, H. Straka, S. L. Wearne, and R. Baker (2006)
J Neurophysiol
96, 1370-1382
| Abstract »
| Full Text »
| PDF »
- The Sniff Is Part of the Olfactory Percept.
- J. Mainland and N. Sobel (2006)
Chem Senses
31, 181-196
| Abstract »
| Full Text »
| PDF »
- Cerebellar Involvement in Anticipating the Consequences of Self-Produced Actions During Bimanual Movements.
- J. Diedrichsen, T. Verstynen, S. L. Lehman, and R. B. Ivry (2005)
J Neurophysiol
93, 801-812
| Abstract »
| Full Text »
| PDF »
- Learning in a Simple Motor System.
- D. M. Broussard and C. D. Kassardjian (2004)
Learn. Mem.
11, 127-136
| Abstract »
| Full Text »
| PDF »
- Reversible Suppression of Glutamatergic Neurotransmission of Cerebellar Granule Cells In Vivo by Genetically Manipulated Expression of Tetanus Neurotoxin Light Chain.
- M. Yamamoto, N. Wada, Y. Kitabatake, D. Watanabe, M. Anzai, M. Yokoyama, Y. Teranishi, and S. Nakanishi (2003)
J. Neurosci.
23, 6759-6767
| Abstract »
| Full Text »
| PDF »
- Computational Study on Monkey VOR Adaptation and Smooth Pursuit Based on the Parallel Control-Pathway Theory.
- H. Tabata, K. Yamamoto, and M. Kawato (2002)
J Neurophysiol
87, 2176-2189
| Abstract »
| Full Text »
| PDF »
- Floccular Modulation of Vestibuloocular Pathways and Cerebellum-Related Plasticity: An In Vitro Whole Brain Study.
- A. L. Babalian and P.-P. Vidal (2000)
J Neurophysiol
84, 2514-2528
| Abstract »
| Full Text »
| PDF »
- Spinal Cord Control of Movement: Implications for Locomotor Rehabilitation Following Spinal Cord Injury.
- E. C. Field-Fote (2000)
Physical Therapy
80, 477-484
| Abstract »
| Full Text »
| PDF »
- Cerebellar Cortex Lesions Prevent Acquisition of Conditioned Eyelid Responses.
- K. S. Garcia, P. M. Steele, and M. D. Mauk (1999)
J. Neurosci.
19, 10940-10947
| Abstract »
| Full Text »
| PDF »
- The Cerebellum's Role in Reading: A Functional MR Imaging Study.
- R. K. Fulbright, A. R. Jenner, W. Einer Mencl, K. R. Pugh, B. A. Shaywitz, S. E. Shaywitz, S. J. Frost, P. Skudlarski, R. Todd Constable, C. M. Lacadie, et al. (1999)
AJNR Am. J. Neuroradiol.
20, 1925-1930
| Abstract »
| Full Text »
- Adaptive Changes in Motor Activity Associated With Functional Recovery Following Muscle Denervation in Walking Cats.
- K. G. Pearson, K. Fouad, and J. E. Misiaszek (1999)
J Neurophysiol
82, 370-381
| Abstract »
| Full Text »
| PDF »
- Neural Control of Rotational Kinematics Within Realistic Vestibuloocular Coordinate Systems.
- M. A. Smith and J. D. Crawford (1998)
J Neurophysiol
80, 2295-2315
| Abstract »
| Full Text »
| PDF »
- Odorant-Induced and Sniff-Induced Activation in the Cerebellum of the Human.
- N. Sobel, V. Prabhakaran, C. A. Hartley, J. E. Desmond, Z. Zhao, G. H. Glover, J. D.E. Gabrieli, and E. V. Sullivan (1998)
J. Neurosci.
18, 8990-9001
| Abstract »
| Full Text »
| PDF »
- Temporal Firing Patterns of Purkinje Cells in the Cerebellar Ventral Paraflocculus During Ocular Following Responses in Monkeys I. Simple Spikes.
- H. Gomi, M. Shidara, A. Takemura, Y. Inoue, K. Kawano, and M. Kawato (1998)
J Neurophysiol
80, 818-831
| Abstract »
| Full Text »
| PDF »
- Primate Head-Free Saccade Generator Implements a Desired (Post-VOR) Eye Position Command by Anticipating Intended Head Motion.
- J. D. Crawford and D. Guitton (1997)
J Neurophysiol
78, 2811-2816
| Abstract »
| Full Text »
| PDF »
- Normal and Adapted Visuooculomotor Reflexes in Goldfish.
- E. Marsh and R. Baker (1997)
J Neurophysiol
77, 1099-1118
| Abstract »
| Full Text »
| PDF »
- Reversible inactivation of the cerebellar interpositus nucleus completely prevents acquisition of the classically conditioned eye-blink response..
- D J Krupa and R F Thompson (1997)
Learn. Mem.
3, 545-556
| Abstract »
| PDF »
- A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum..
- M D Mauk and N H Donegan (1997)
Learn. Mem.
4, 130-158
| Abstract »
| PDF »
- Memory systems in the brain and localization of a memory.
- R. F. Thompson and J. J. Kim (1996)
PNAS
93, 13438-13444
| Abstract »
| Full Text »
| PDF »
- Properties of Pathways That Mediate Motor Learning in the Vestibulo-ocular Reflex of Monkeys.
- S.G. Lisberger, D.M. Broussard, and H.M. Bronte-Stewart (1990)
Cold Spring Harb Symp Quant Biol
55, 813-822
| Abstract »
| PDF »
- Perspectives on cognitive neuroscience.
- P. Churchland and T. Sejnowski (1988)
Science
242, 741-745
| Abstract »
| PDF »
- Cerebellar cortical inhibition and classical eyeblink conditioning.
- S. Bao, L. Chen, J. J. Kim, and R. F. Thompson (2002)
PNAS
99, 1592-1597
| Abstract »
| Full Text »
| PDF »
|
|
