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Science 18 November 1988:
Vol. 242. no. 4881, pp. 1042 - 1045
DOI: 10.1126/science.3194754
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Articles

Science, Vol 242, Issue 4881, 1042-1045
Copyright © 1988 by American Association for the Advancement of Science

articles

Cloning of a membrane protein that induces a slow voltage-gated potassium current

T Takumi, H Ohkubo, and S Nakanishi

Institute for Immunology, Kyoto University Faculty of Medicine, Japan.

A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.


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KCNQ5, a Novel Potassium Channel Broadly Expressed in Brain, Mediates M-type Currents.
B. C. Schroeder, M. Hechenberger, F. Weinreich, C. Kubisch, and T. J. Jentsch (2000)
J. Biol. Chem. 275, 24089-24095
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Identification of Specific Pore Residues Mediating KCNQ1 Inactivation. A NOVEL MECHANISM FOR LONG QT SYNDROME.
G. Seebohm, C. R. Scherer, A. E. Busch, and C. Lerche (2001)
J. Biol. Chem. 276, 13600-13605
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Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome.
I. Arrighi, M. Bloch-Faure, F. Grahammer, M. Bleich, R. Warth, R. Mengual, M.-D. Drici, J. Barhanin, and P. Meneton (2001)
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   Abstract »    Full Text »    PDF »


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