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Science 18 November 1988:
Vol. 242. no. 4881, pp. 1058 - 1061
DOI: 10.1126/science.3194758
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Articles

Science, Vol 242, Issue 4881, 1058-1061
Copyright © 1988 by American Association for the Advancement of Science

articles

Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene

T Yilma, D Hsu, L Jones, S Owens, M Grubman, C Mebus, M Yamanaka, and B Dale

Department of Veterinary Microbiology and Immunology, University of California, Davis 95616.

Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90% mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.


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Development of a Dual Recombinant Vaccine To Protect Small Ruminants against Peste-des-Petits-Ruminants Virus and Capripoxvirus Infections.
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Identification of Immunodominant Neutralizing Epitopes on the Hemagglutinin Protein of Rinderpest Virus.
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Long-Term Sterilizing Immunity to Rinderpest in Cattle Vaccinated with a Recombinant Vaccinia Virus Expressing High Levels of the Fusion and Hemagglutinin Glycoproteins.
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Recovery and Characterization of a Chimeric Rinderpest Virus with the Glycoproteins of Peste-des-Petits-Ruminants Virus: Homologous F and H Proteins Are Required for Virus Viability.
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Long-term protective immunity to rinderpest in cattle following a single vaccination with a recombinant vaccinia virus expressing the virus haemagglutinin protein.
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B Moss (1991)
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