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Science 25 November 1988:
Vol. 242. no. 4882, pp. 1164 - 1166
DOI: 10.1126/science.3055302
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Articles

Science, Vol 242, Issue 4882, 1164-1166
Copyright © 1988 by American Association for the Advancement of Science

articles

Intron existence predated the divergence of eukaryotes and prokaryotes

MC Shih, P Heinrich, and HM Goodman

Department of Genetics, Harvard Medical School, Boston, MA.

Nucleotide sequences for the nuclear genes encoding chloroplast (GapA and GapB) and cytosolic (GapC) glyceraldehyde-3-phosphate dehydrogenases (GAPDHs) from Arabidopsis thaliana were determined. Comparison of nucleotide sequences indicates that the divergence of chloroplast and cytosolic GAPDH genes preceded the divergence of prokaryotes and eukaryotes. In addition, some intron-exon junctions are conserved among GapB, GapC, and chicken GAPDH genes. These results provide evidence at the molecular level to support the idea that introns existed before the divergence of prokaryotes and eukaryotes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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E. C. McKinney and R. B. Meagher (1998)
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How big is the universe of exons?.
R. Dorit, L Schoenbach, and W Gilbert (1990)
Science 250, 1377-1382
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