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Science 16 December 1988:
Vol. 242. no. 4885, pp. 1570 - 1572
DOI: 10.1126/science.3144044
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Articles

Science, Vol 242, Issue 4885, 1570-1572
Copyright © 1988 by American Association for the Advancement of Science

articles

The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs

S Robinow, AR Campos, KM Yao, and K White

Department of Biology, Brandeis University, Waltham, MA 02254-9110.

A sequence of developmental events transforms neurons from their immature state to their mature, terminally differentiated state. The elav locus is one of the first examples of a gene that is expressed in neurons early during this developmental sequence. This gene has been shown to be required for the proper development of young neurons and for the maintenance of mature neurons. DNA sequence data presented in this report suggest that the elav gene product is an RNA binding protein, based on the presence of RNP (ribonucleoprotein) consensus sequences. This leads to the proposal that this protein is involved in the RNA metabolism of neurons.


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The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation.
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Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems.
W. Akamatsu, H. J. Okano, N. Osumi, T. Inoue, S. Nakamura, S.-I. Sakakibara, M. Miura, N. Matsuo, R. B. Darnell, and H. Okano (1999)
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A Hierarchy of Hu RNA Binding Proteins in Developing and Adult Neurons.
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Sequential expression and role of Hu RNA-binding proteins during neurogenesis.
Y Wakamatsu and J. Weston (1997)
Development 124, 3449-3460
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Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A..
X Dong, K H Zavitz, B J Thomas, M Lin, S Campbell, and S L Zipursky (1997)
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Differential Activity of ELAV-like RNA-binding Proteins in Human Neuroblastoma.
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Development 122, 1601-1610
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Molecular Characterization of the Protein Products of the Fragile X Syndrome Gene and the Survival of Motor Neurons Gene.
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Conserved structures and diversity of functions of RNA-binding proteins.
C. Burd and G Dreyfuss (1994)
Science 265, 615-621
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A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex..
J W Erickson and T W Cline (1993)
Genes & Dev. 7, 1688-1702
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The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein..
E J Michaud, S J Bultman, L J Stubbs, and R P Woychik (1993)
Genes & Dev. 7, 1203-1213
   Abstract »    PDF »
Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene..
R L Kelley (1993)
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   Abstract »    PDF »
deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product..
E Bier, H Vaessin, S Younger-Shepherd, L Y Jan, and Y N Jan (1992)
Genes & Dev. 6, 2137-2151
   Abstract »    PDF »
Characterization of cDNAs encoding the polypyrimidine tract-binding protein..
A Gil, P A Sharp, S F Jamison, and M A Garcia-Blanco (1991)
Genes & Dev. 5, 1224-1236
   Abstract »    PDF »
Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing..
J G Patton, S A Mayer, P Tempst, and B Nadal-Ginard (1991)
Genes & Dev. 5, 1237-1251
   Abstract »    PDF »
Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs..
K W Shannon and C Guthrie (1991)
Genes & Dev. 5, 773-785
   Abstract »    PDF »
Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments..
A C Hart, H Kramer, D L Van Vactor, M Paidhungat, and S L Zipursky (1990)
Genes & Dev. 4, 1835-1847
   Abstract »    PDF »
Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog.
F. Gertler, J. Doctor, and F. Hoffmann (1990)
Science 248, 857-860
   Abstract »    PDF »
Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector..
E Bier, H Vaessin, S Shepherd, K Lee, K McCall, S Barbel, L Ackerman, R Carretto, T Uemura, and E Grell (1989)
Genes & Dev. 3, 1273-1287
   Abstract »    PDF »
RNA-binding proteins as developmental regulators..
R J Bandziulis, M S Swanson, and G Dreyfuss (1989)
Genes & Dev. 3, 431-437
   PDF »
Drosophila Arginase Is Produced from a Nonvital Gene That Contains the elav Locus within Its Third Intron.
M.-L. Samson (2000)
J. Biol. Chem. 275, 31107-31114
   Abstract »    Full Text »    PDF »
A 5' Leader of Rbm3, a Cold Stress-induced mRNA, Mediates Internal Initiation of Translation with Increased Efficiency under Conditions of Mild Hypothermia.
S. A. Chappell, G. C. Owens, and V. P. Mauro (2001)
J. Biol. Chem. 276, 36917-36922
   Abstract »    Full Text »    PDF »
HuD, a Neuronal-specific RNA-binding Protein, Increases the in Vivo Stability of MYCN RNA.
C. F. Manohar, M. L. Short, A. Nguyen, N. N. Nguyen, D. Chagnovich, Q. Yang, and S. L. Cohn (2002)
J. Biol. Chem. 277, 1967-1973
   Abstract »    Full Text »    PDF »


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