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Science 23 December 1988:
Vol. 242. no. 4886, pp. 1665 - 1670
DOI: 10.1126/science.3201255
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Articles

Science, Vol 242, Issue 4886, 1665-1670
Copyright © 1988 by American Association for the Advancement of Science

articles

Development of disease and virus recovery in transgenic mice containing HIV proviral DNA

JM Leonard, JW Abramczuk, DS Pezen, R Rutledge, JH Belcher, F Hakim, G Shearer, L Lamperth, W Travis, T Fredrickson, and al. et

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.

Transgenic mice containing intact copies of the human immunodeficiency virus (HIV) proviral DNA were constructed. Founder animals were not viremic for HIV and remained healthy during a 9-month observation period. After being mated with nontransgenic animals, one founder mouse (No. 13) gave rise to F1 progeny that developed a disease syndrome characterized by marked epidermal hyperplasia, lymphadenopathy, splenomegaly, pulmonary lymphoid infiltrates, growth retardation, and death by day 25 of life. Infectious HIV, indistinguishable from parental virus by immunoblot analysis, was recovered from the spleen, lymph nodes, and skin of five of five affected animals.


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