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Science 23 December 1988:
Vol. 242. no. 4886, pp. 1687 - 1691
DOI: 10.1126/science.3201257
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Articles

Science, Vol 242, Issue 4886, 1687-1691
Copyright © 1988 by American Association for the Advancement of Science

articles

Movement of the X chromosome in epilepsy

J Borden and L Manuelidis

Yale University School of Medicine, New Haven, CT 06510.

The position of selected chromosomes was assessed in samples of normal and epileptic human cortex with biotinylated probes specific for individual chromosome domains. Optical sectioning provided a rapid method for three-dimensional resolution of in situ hybridization signals in interphase cells, and solid models were reconstructed from digitized images for detailed rotational studies. There was a dramatic repositioning of the X chromosome in neurons of both males and females in electrophysiologically defined seizure foci. Other chromosomes (1, 9, and Y) showed more subtle positional changes. Specifically altered nuclear patterns involving the X chromosome may become established and create the genetic memory for intractable seizure activity.


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