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Science 11 August 1989:
Vol. 245. no. 4918, pp. 651 - 653
DOI: 10.1126/science.2569763
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Articles

Science, Vol 245, Issue 4918, 651-653
Copyright © 1989 by American Association for the Advancement of Science

articles

A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein

F de Sauvage and JN Octave

Laboratoire de Neurochimie, Universite Catholique de Louvain, Bruxelles, Belgium.

The gene, encoding the A4 peptide found in the amyloid core of senile plaques isolated from the cerebral cortex of patients with Alzheimer's disease, produces at least three precursors that resemble cell surface receptors. A clone isolated from a human brain complementary DNA library contained the structural sequence for an A4 amyloid peptide precursor with a serine protease inhibitor domain in which 208 amino acids at the carboxyl terminal are replaced by 20 amino acids derived from nucleotide sequences with homology to the Alu repeat family. This protein devoid of the transmembrane domain most likely represents a secreted form of the A4 amyloid peptide precursor.


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Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.
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