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Science 25 August 1989:
Vol. 245. no. 4920, pp. 850 - 852
DOI: 10.1126/science.2549636
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Articles

Science, Vol 245, Issue 4920, 850-852
Copyright © 1989 by American Association for the Advancement of Science

articles

Nutritional importance of pyrroloquinoline quinone

J Killgore, C Smidt, L Duich, N Romero-Chapman, D Tinker, K Reiser, M Melko, D Hyde, and RB Rucker

Department of Nutrition, School of Agricultural and Environmental Sciences, University of California, Davis 95616.

Mice fed a chemically defined diet devoid of pyrroloquinoline quinone (PQQ) grew poorly, failed to reproduce, and became osteolathyritic. Moreover, severely affected mice had friable skin, skin collagen that was readily extractable into neutral salt solutions, and decreased lysyl oxidase. The identification of functional defects in connective tissue and the growth retardation associated with PQQ deprivation suggest that PQQ plays a fundamental role as a growth factor or vitamin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pyrroloquinoline Quinone Is a Plant Growth Promotion Factor Produced by Pseudomonas fluorescens B16.
O. Choi, J. Kim, J.-G. Kim, Y. Jeong, J. S. Moon, C. S. Park, and I. Hwang (2008)
Plant Physiology 146, 657-668
   Abstract »    Full Text »    PDF »
Pyrroloquinoline Quinone Modulates Mitochondrial Quantity and Function in Mice.
T. Stites, D. Storms, K. Bauerly, J. Mah, C. Harris, A. Fascetti, Q. Rogers, E. Tchaparian, M. Satre, and R. B. Rucker (2006)
J. Nutr. 136, 390-396
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New Quinocofactors in Eukaryotes.
J. P. Klinman and J. P. Klinman (1996)
J. Biol. Chem. 271, 27189-27192
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A new cofactor in a prokaryotic enzyme: tryptophan tryptophylquinone as the redox prosthetic group in methylamine dehydrogenase.
W. McIntire, D. Wemmer, A Chistoserdov, and M. Lidstrom (1991)
Science 252, 817-824
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A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase.
S. Janes, D Mu, D Wemmer, A. Smith, S Kaur, D Maltby, A. Burlingame, and J. Klinman (1990)
Science 248, 981-987
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