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Science 15 September 1989:
Vol. 245. no. 4923, pp. 1238 - 1241
DOI: 10.1126/science.2551036
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Articles

Science, Vol 245, Issue 4923, 1238-1241
Copyright © 1989 by American Association for the Advancement of Science

articles

Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors

TK Kishimoto, MA Jutila, EL Berg, and EC Butcher

Department of Pathology, Stanford University, CA 94305.

The neutrophil Mac-1 and gp100MEL-14 adhesion proteins are involved in neutrophil extravasation during inflammation. Both the expression and activity of Mac-1 are greatly increased after neutrophil activation. In contrast, neutrophils shed gp100MEL-14 from the cell surface within 4 minutes after activation with chemotactic factors or phorbol esters, releasing a 96-kilodalton fragment of the antigen into the supernatant. Immunohistology showed that gp100MEL-14 was downregulated on neutrophils that had extravasated into inflamed tissue. The gp100MEL-14 adhesion protein may participate in the binding of unactivated neutrophils to the endothelium; rapid shedding of gp100MEL-14 may prevent extravasation into and damage of normal tissues by activated neutrophils.


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   Abstract »    Full Text »    PDF »
Down-regulation of L-selectin expression in neutrophils by nonsteroidal anti-inflammatory drugs: role of intracellular ATP concentration.
M. V. Gomez-Gaviro, C. Dominguez-Jimenez, J. M. Carretero, P. Sabando, I. Gonzalez-Alvaro, F. Sanchez-Madrid, and F. Diaz-Gonzalez (2000)
Blood 96, 3592-3600
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P-Selectin-Dependent Inhibition of Thrombosis During Venous Stasis.
M. J. Eppihimer and R. G. Schaub (2000)
Arterioscler. Thromb. Vasc. Biol. 20, 2483-2488
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Chemotaxis of chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor: role of signal transduction molecules and alpha5beta1 integrin.
H. Miettinen, J. Gripentrog, and A. Jesaitis (2000)
J. Cell Sci. 111, 1921-1928
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STIMULATION OF NEUTROPHIL INTEGRIN EXPRESSION DURING CORONARY ARTERY BYPASS GRAFTING: COMPARISON OF CRYSTALLOID AND BLOOD CARDIOPLEGIC SOLUTIONS.
R. Kalawski, E. Deskur, P. Bugajski, H. Wysocki, and T. Siminiak (2000)
J. Thorac. Cardiovasc. Surg. 119, 1270-1277
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Stimulation-induced Down-regulation of Tumor Necrosis Factor-alpha Converting Enzyme.
J. R. Doedens and R. A. Black (2000)
J. Biol. Chem. 275, 14598-14607
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