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Science 13 October 1989:
Vol. 246. no. 4927, pp. 243 - 247
DOI: 10.1126/science.2799384
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Articles

Science, Vol 246, Issue 4927, 243-247
Copyright © 1989 by American Association for the Advancement of Science

articles

Detection of cell-affecting agents with a silicon biosensor

JW Parce, JC Owicki, KM Kercso, GB Sigal, HG Wada, VC Muir, LJ Bousse, KL Ross, BI Sikic, and HM McConnell

Molecular Devices Corporation, Menlo Park, CA 94025.

Cellular metabolism is affected by many factors in a cell's environment. Given a sufficiently sensitive method for measuring cellular metabolic rates, it should be possible to detect a wide variety of chemical and physical stimuli. A biosensor has been constructed in which living cells are confined to a flow chamber in which a potentiometric sensor continually measures the rate of production of acidic metabolites. Exploratory studies demonstrate several applications of the device in basic science and technology.


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Single cells as biosensors for chemical separations.
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Structure-Based Strategies for Drug Design and Discovery.
I. D. Kuntz (1992)
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Identification and Characterization of a Potent, Selective, and Orally Active Antagonist of the CC Chemokine Receptor-1.
M. Liang, C. Mallari, M. Rosser, H. P. Ng, K. May, S. Monahan, J. G. Bauman, I. Islam, A. Ghannam, B. Buckman, et al. (2000)
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