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Science 13 October 1989:
Vol. 246. no. 4927, pp. 249 - 251
DOI: 10.1126/science.2799385
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Articles

Science, Vol 246, Issue 4927, 249-251
Copyright © 1989 by American Association for the Advancement of Science

articles

Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1

K Muegge, TM Williams, J Kant, M Karin, R Chiu, A Schmidt, U Siebenlist, HA Young, and SK Durum

Laboratory of Molecular Immunoregulation, Program Resources Inc., Frederick, MD 21701.

Interleukin-1 (IL-1) is a major regulator of inflammation and immunity. IL-1 induces T lymphocyte growth by acting as a second signal (together with antigen) in enhancing the production of interleukin-2 (IL-2). An IL-1-responsive element in the promoter region of the human IL-2 gene was similar to the binding site for the transcription factor AP-1. IL-1 enhanced expression of c-jun messenger RNA, whereas the antigenic signal enhanced messenger RNA expression of c-fos. Thus, the two components of the AP-1 factor are independently regulated and the AP-1 factor may serve as a nuclear mediator for the many actions of IL-1 on cells.


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