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Science 20 October 1989:
Vol. 246. no. 4928, pp. 371 - 373
DOI: 10.1126/science.246.4928.371
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Articles

Toward Protein Tertiary Structure Recognition by Means of Associative Memory Hamiltonians

MARK S. FRIEDRICHS 1 and PETER G. WOLYNES 1

1 School of Chemical Sciences and Beckman Institute, University of Illinois, Urbana, IL 61801.

The statistical mechanics of associative memories and spin glasses suggests ways to design Hamiltonians for protein folding. An associative memory Hamiltonian based on hydrophobicity patterns is shown to have a large capacity for recall and to be capable of recognizing tertiary structure for moderately variant sequences.

Submitted on June 9, 1989
Accepted on September 13, 1989


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