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Science 20 October 1989:
Vol. 246. no. 4928, pp. 379 - 382
DOI: 10.1126/science.2799390
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Articles
Science, Vol 246, Issue 4928, 379-382
Copyright © 1989 by American Association for the Advancement of Science
The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias
JD Mellentin,
C Murre,
TA Donlon,
PS McCaw,
SD Smith,
AJ Carroll,
ME McDonald,
D Baltimore,
and
ML Cleary
Department of Pathology, Stanford University School of Medicine, CA 94025.
The gene (E2A) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12/E47 was mapped to chromosome region 19p13.2-p13.3, a site associated with nonrandom translocations in acute lymphoblastic leukemias. The majority of t(1;19)(q23;p13)-carrying leukemias and cell lines studied contained rearrangements of E2A as determined by DNA blot analyses. The rearrangements altered the E2A transcriptional unit, resulting in the synthesis of a transcript larger than the normal-sized E2A mRNAs in one of the cell lines with this translocation. These observations indicate that the gene for a transcription factor is located at the breakpoint of a consistently recurring chromosomal translocation in many acute leukemias and suggest a direct role for alteration of such factors in the pathogenesis of some malignancies.
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