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Science 3 November 1989:
Vol. 246. no. 4930, pp. 609 - 614
DOI: 10.1126/science.2683076
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Articles

Science, Vol 246, Issue 4930, 609-614
Copyright © 1989 by American Association for the Advancement of Science

articles

S phase of the cell cycle

RA Laskey, MP Fairman, and JJ Blow

Department of Zoology, University of Cambridge, England.

In each cell cycle the complex structure of the chromosome must be replicated accurately. In the last few years there have been major advances in understanding eukaryotic chromosome replication. Patterns of replication origins have been mapped accurately in yeast chromosomes. Cellular replication proteins have been identified by fractionating cell extracts that replicate viral DNA templates in vitro. Cell-free systems that initiate eukaryotic DNA replication in vitro have demonstrated the importance of complex nuclear architecture in the control of DNA replication. Although the events of S phase were relatively neglected for many years, knowledge of DNA replication is now advancing rapidly in step with other phases of the cell cycle.


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