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Science 3 November 1989:
Vol. 246. no. 4930, pp. 614 - 621
DOI: 10.1126/science.2683077

Articles

Science, Vol 246, Issue 4930, 614-621
Copyright © 1989 by American Association for the Advancement of Science


articles

Dominoes and clocks: the union of two views of the cell cycle

AW Murray and MW Kirschner

Department of Physiology, School of Medicine, University of California, San Francisco 94143-0448.

We review the recent advances in understanding transitions within the cell cycle. These have come from both genetic and biochemical approaches. We discuss the phylogenetic conservation of the mechanisms that induce mitosis and their implications for other transitions in the cell cycle.


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Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2..
H Richardson, D J Lew, M Henze, K Sugimoto, and S I Reed (1992)
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Fission yeast genes involved in coupling mitosis to completion of DNA replication..
T Enoch, A M Carr, and P Nurse (1992)
Genes & Dev. 6, 2035-2046
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CLB5: a novel B cyclin from budding yeast with a role in S phase..
C B Epstein and F R Cross (1992)
Genes & Dev. 6, 1695-1706
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Direct induction of G1-specific transcripts following reactivation of the Cdc28 kinase in the absence of de novo protein synthesis..
N J Marini and S I Reed (1992)
Genes & Dev. 6, 557-567
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Temporal regulation of gene expression in the blastoderm Drosophila embryo..
G K Yasuda, J Baker, and G Schubiger (1991)
Genes & Dev. 5, 1800-1812
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Differential phosphorylation of the transcription factor Oct1 during the cell cycle.
S. Roberts, N Segil, and N Heintz (1991)
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The ras oncoprotein and M-phase activity.
I Daar, A. Nebreda, N Yew, P Sass, R Paules, E Santos, M Wigler, and G. Vande Woude (1991)
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A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1)..
J H Shero and P Hieter (1991)
Genes & Dev. 5, 549-560
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A model for the adjustment of the mitotic clock by cyclin and MPF levels.
R Norel and Z Agur (1991)
Science 251, 1076-1078
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Ability of the c-mos product to associate with and phosphorylate tubulin.
R. Zhou, M Oskarsson, R. Paules, N Schulz, D Cleveland, and G. Vande Woude (1991)
Science 251, 671-675
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G1 Control in Yeast and Animal Cells.
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Cold Spring Harb Symp Quant Biol 56, 61-67
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The Cyclin-dependent Kinase Family.
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Cold Spring Harb Symp Quant Biol 56, 177-186
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Fidelity of Mitotic Chromosome Transmission.
M. Brown, B. Garvik, L. Hartwell, L. Kadyk, T. Seeley, and T. Weinert (1991)
Cold Spring Harb Symp Quant Biol 56, 359-365
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Coordinating Cell Cycle Events.
A.W. Murray (1991)
Cold Spring Harb Symp Quant Biol 56, 399-408
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Control of p34cdc2 Activation.
M.J. Solomon, J. Gautier, T. Lee, and M.W. Kirschner (1991)
Cold Spring Harb Symp Quant Biol 56, 427-435
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Mos and Ras: Two Oncoproteins That Display M-phase Activity.
I. Daar, R. Zhou, R.-L. Shen, A. Nebreda, M. Oskarsson, E. Santos, P. Pinto da Silva, Y. Masui, and G.F. Vande Woude (1991)
Cold Spring Harb Symp Quant Biol 56, 477-488
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Regulation of Protein Kinases Associated with Cyclin A and Cyclin B and Their Effect on Microtubule Dynamics and Nucleation in Xenopus Egg Extracts.
B. Buendia, P.R. Clarke, M.A. Felix, E. Karsenti, D. Leiss, and F. Verde (1991)
Cold Spring Harb Symp Quant Biol 56, 523-532
   Abstract »    PDF »
Vertebrate cdc2 Kinase: Its Regulation by Phosphorylation and Its Mitotic Targets.
E.A. Nigg, W. Krek, and M. Peter (1991)
Cold Spring Harb Symp Quant Biol 56, 539-547
   Abstract »    PDF »
Role of the Cell-cycle-regulated NIMA Protein Kinase during G2 and Mitosis: Evidence for Two Pathways of Mitotic Regulation.
A.H. Osmani, S.L. McGuire, K.L. O'Donnell, R.T. Pu, and S.A. Osmani (1991)
Cold Spring Harb Symp Quant Biol 56, 549-555
   Abstract »    PDF »
cdc25 M-phase Inducer.
J. Millar, C. McGowan, R. Jones, K. Sadhu, A. Bueno, H. Richardson, and P. Russell (1991)
Cold Spring Harb Symp Quant Biol 56, 577-584
   Abstract »    PDF »
Meiotic Chromosome Metabolism: One View.
N. Kleckner, R. Padmore, and D.K. Bishop (1991)
Cold Spring Harb Symp Quant Biol 56, 729-743
   Abstract »    PDF »
Summary: Put Out More Flags.
T. Hunt (1991)
Cold Spring Harb Symp Quant Biol 56, 757-769
   Abstract »    PDF »
Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.
K. Gould, S Moreno, N. Tonks, and P Nurse (1990)
Science 250, 1573-1576
   Abstract »    PDF »
bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis..
D M McKearin and A C Spradling (1990)
Genes & Dev. 4, 2242-2251
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Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase.
G D'Urso, R. Marraccino, D. Marshak, and J. Roberts (1990)
Science 250, 786-791
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Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe..
H E Richardson, C S Stueland, J Thomas, P Russell, and S I Reed (1990)
Genes & Dev. 4, 1332-1344
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Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells..
S Din, S J Brill, M P Fairman, and B Stillman (1990)
Genes & Dev. 4, 968-977
   Abstract »    PDF »
G1 events and regulation of cell proliferation.
A. Pardee (1989)
Science 246, 603-608
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S phase of the cell cycle.
R. Laskey, M. Fairman, and J. Blow (1989)
Science 246, 609-614
   Abstract »    PDF »
Checkpoints: controls that ensure the order of cell cycle events.
L. Hartwell and T. Weinert (1989)
Science 246, 629-634
   Abstract »    PDF »
Directing cell division during development.
P. O'Farrell, B. Edgar, D Lakich, and C. Lehner (1989)
Science 246, 635-640
   Abstract »    PDF »



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