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Science 3 November 1989:
Vol. 246. no. 4930, pp. 668 - 670
DOI: 10.1126/science.2814489
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Articles

Science, Vol 246, Issue 4930, 668-670
Copyright © 1989 by American Association for the Advancement of Science

articles

Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides

MD Howell, ST Winters, T Olee, HC Powell, DJ Carlo, and SW Brostoff

Immune Response Corporation, San Diego, CA 92121.

Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system mediated by CD4+ T cells reactive with myelin basic protein (MBP). Rats were rendered resistant to the induction of EAE by vaccination with synthetic peptides corresponding to idiotypic determinants of the beta chain VDJ region and J alpha regions of the T cell receptor (TCR) that are conserved among encephalitogenic T cells. These findings demonstrate the utility of TCR peptide vaccination for modulating the activity of autoreactive T cells and represent a general therapeutic approach for T cell-mediated pathogenesis.


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