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Science 10 November 1989:
Vol. 246. no. 4931, pp. 808 - 810
DOI: 10.1126/science.2683084
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Articles

Science, Vol 246, Issue 4931, 808-810
Copyright © 1989 by American Association for the Advancement of Science

articles

Chromosomal location and evolutionary rate variation in enterobacterial genes

PM Sharp, DC Shields, KH Wolfe, and WH Li

Department of Genetics, Trinity College, Dublin, Ireland.

The basal rate of DNA sequence evolution in enterobacteria, as seen in the extent of divergence between Escherichia coli and Salmonella typhimurium, varies greatly among genes, even when only "silent" sites are considered. The degree of divergence is clearly related to the level of gene expression, reflecting constraints on synonymous codon choice. However, where this constraint is weak, among genes not expressed at high levels, divergence is also related to the chromosomal location of the gene; it appears that genes furthest away from oriC, the origin of replication, have a mutation rate approximately two times that of genes near oriC.


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