Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 November 1989:
Vol. 246. no. 4932, pp. 919 - 922
DOI: 10.1126/science.2814514
Prev | Table of Contents | Next

Articles

Science, Vol 246, Issue 4932, 919-922
Copyright © 1989 by American Association for the Advancement of Science

articles

Molecular mechanisms and forces involved in the adhesion and fusion of amphiphilic bilayers

CA Helm, JN Israelachvili, and PM McGuiggan

Department of Chemical and Nuclear Engineering, University of California, Santa Barbara 93106.

The surface forces apparatus technique was used for measuring the adhesion, deformation, and fusion of bilayers supported on mica surfaces in aqueous solutions. The most important force leading to the direct fusion of bilayers is the hydrophobic interaction, although the occurrence of fusion is not simply related to the force law between bilayers. Bilayers do not need to "overcome" some repulsive force barrier, such as hydration, before they can fuse. Instead, once bilayer surfaces come within about 1 nanometer of each other, local deformations and molecular rearrangements allow them to "bypass" these forces.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Locking the Kink in the Influenza Hemagglutinin Fusion Domain Structure.
A. L. Lai and L. K. Tamm (2007)
J. Biol. Chem. 282, 23946-23956
   Abstract »    Full Text »    PDF »
Triggering and Visualizing the Aggregation and Fusion of Lipid Membranes in Microfluidic Chambers.
D. J. Estes, S. R. Lopez, A. O. Fuller, and M. Mayer (2006)
Biophys. J. 91, 233-243
   Abstract »    Full Text »    PDF »
Identification of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Exocytotic Machinery in Human Plasma Cells: SNAP-23 Is Essential for Antibody Secretion.
E. Reales, F. Mora-Lopez, V. Rivas, A. Garcia-Poley, J. A. Brieva, and A. Campos-Caro (2005)
J. Immunol. 175, 6686-6693
   Abstract »    Full Text »    PDF »
Using the Atomic Force Microscope to Study the Interaction between Two Solid Supported Lipid Bilayers and the Influence of Synapsin I.
I. Pera, R. Stark, M. Kappl, H.-J. Butt, and F. Benfenati (2004)
Biophys. J. 87, 2446-2455
   Abstract »    Full Text »    PDF »
Correlation of AFM and SFA Measurements Concerning the Stability of Supported Lipid Bilayers.
M. Benz, T. Gutsmann, N. Chen, R. Tadmor, and J. Israelachvili (2004)
Biophys. J. 86, 870-879
   Abstract »    Full Text »    PDF »
Initiation and Dynamics of Hemifusion in Lipid Bilayers.
G. Hed and S. A. Safran (2003)
Biophys. J. 85, 381-389
   Abstract »    Full Text »    PDF »
Energy of Hydrogen Bonds Probed by the Adhesion of Functionalized Lipid Layers.
D. Tareste, F. Pincet, E. Perez, S. Rickling, C. Mioskowski, and L. Lebeau (2002)
Biophys. J. 83, 3675-3681
   Abstract »    Full Text »    PDF »
Lipid Intermediates in Membrane Fusion: Formation, Structure, and Decay of Hemifusion Diaphragm.
Y. Kozlovsky, L. V. Chernomordik, and M. M. Kozlov (2002)
Biophys. J. 83, 2634-2651
   Abstract »    Full Text »    PDF »
Molecular Organization of Surfactants at Solid-Liquid Interfaces.
S. Manne and H. E. Gaub (1995)
Science 270, 1480-1482
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)