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Science 24 November 1989:
Vol. 246. no. 4933, pp. 1023 - 1025
DOI: 10.1126/science.2587985
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Articles

Science, Vol 246, Issue 4933, 1023-1025
Copyright © 1989 by American Association for the Advancement of Science

articles

Purification, cloning, and expression of ciliary neurotrophic factor (CNTF)

LF Lin, D Mismer, JD Lile, LG Armes, ET Butler 3rd, JL Vannice, and F Collins

Protein Chemistry Group, Synergen, Inc., Boulder, CO 80301.

Ciliary neurotrophic factor (CNTF) is one of a small number of proteins with neurotrophic activities distinct from nerve growth factor (NGF). CNTF has now been purified and cloned and the primary structure of CNTF from rabbit sciatic nerve has been determined. Biologically active CNTF has been transiently expressed from a rabbit complementary DNA clone. CNTF is a neural effector without significant sequence homologies to any previously reported protein.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor {alpha} Chain.
F. Rousseau, S. Chevalier, C. Guillet, E. Ravon, C. Diveu, J. Froger, F. Barbier, L. Grimaud, and H. Gascan (2008)
J. Biol. Chem. 283, 30341-30350
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A Novel Immunoprecipitation Strategy Identifies a Unique Functional Mimic of the Glial Cell Line-Derived Neurotrophic Factor Family Ligands in the Pathogen Trypanosoma cruzi.
B. Lu and M. PereiraPerrin (2008)
Infect. Immun. 76, 3530-3538
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Regulation of Rod Phototransduction Machinery by Ciliary Neurotrophic Factor.
R. Wen, Y. Song, S. Kjellstrom, A. Tanikawa, Y. Liu, Y. Li, L. Zhao, R. A. Bush, A. M. Laties, and P. A. Sieving (2006)
J. Neurosci. 26, 13523-13530
   Abstract »    Full Text »    PDF »
Continued Administration of Ciliary Neurotrophic Factor Protects Mice from Inflammatory Pathology in Experimental Autoimmune Encephalomyelitis.
T. Kuhlmann, L. Remington, I. Cognet, L. Bourbonniere, S. Zehntner, F. Guilhot, A. Herman, A. Guay-Giroux, J. P. Antel, T. Owens, et al. (2006)
Am. J. Pathol. 169, 584-598
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Phylogeny and evolution of class-I helical cytokines..
M. O Huising, C. P Kruiswijk, and G. Flik (2006)
J. Endocrinol. 189, 1-25
   Abstract »    Full Text »    PDF »
Loss of Leukemia Inhibitory Factor Receptor beta or Cardiotrophin-1 Causes Similar Deficits in Preganglionic Sympathetic Neurons and Adrenal Medulla.
S. Oberle, A. Schober, V. Meyer, B. Holtmann, C. Henderson, M. Sendtner, and K. Unsicker (2006)
J. Neurosci. 26, 1823-1832
   Abstract »    Full Text »    PDF »
Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp130 signaling.
M. Stanke, C. V. Duong, M. Pape, M. Geissen, G. Burbach, T. Deller, H. Gascan, R. Parlato, G. Schutz, and H. Rohrer (2006)
Development 133, 141-150
   Abstract »    Full Text »    PDF »
Cross-talk among gp130 Cytokines in Adipocytes.
S. Zvonic, J. E. Baugh Jr., P. Arbour-Reily, R. L. Mynatt, and J. M. Stephens (2005)
J. Biol. Chem. 280, 33856-33863
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Rapid protein kinase C-dependent reduction of rat skeletal muscle voltage-gated sodium channels by ciliary neurotrophic factor.
S Talon, M.-A Giroux-Metges, J.-P Pennec, C Guillet, H Gascan, and M Gioux (2005)
J. Physiol. 565, 827-841
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The Peptides ADNF-9 and NAP Increase Survival and Neurite Outgrowth of Rat Retinal Ganglion Cells In Vitro.
W. A. Lagreze, A. Pielen, R. Steingart, G. Schlunck, H.-D. Hofmann, I. Gozes, and M. Kirsch (2005)
Invest. Ophthalmol. Vis. Sci. 46, 933-938
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The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor {alpha} Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription Pathway.
M. A. Ozog, S. M. Bernier, D. C. Bates, B. Chatterjee, C. W. Lo, and C. C.G. Naus (2004)
Mol. Biol. Cell 15, 4761-4774
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Signaling of Human Ciliary Neurotrophic Factor (CNTF) Revisited. THE INTERLEUKIN-6 RECEPTOR CAN SERVE AS AN alpha -RECEPTOR FOR CNTF.
B. Schuster, M. Kovaleva, Y. Sun, P. Regenhard, V. Matthews, J. Grotzinger, S. Rose-John, and K.-J. Kallen (2003)
J. Biol. Chem. 278, 9528-9535
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The Regulation and Activation of Ciliary Neurotrophic Factor Signaling Proteins in Adipocytes.
S. Zvonic, P. Cornelius, W. C. Stewart, R. L. Mynatt, and J. M. Stephens (2003)
J. Biol. Chem. 278, 2228-2235
   Abstract »    Full Text »    PDF »
GDNF and neurturin are target-derived factors essential for cranial parasympathetic neuron development.
E. Hashino, M. Shero, D. Junghans, H. Rohrer, J. Milbrandt, and E. M. Johnson Jr. (2001)
Development 128, 3773-3782
   Abstract »    Full Text »    PDF »
Upregulation of Ciliary Neurotrophic Factor (CNTF) and CNTF Receptor {{alpha}} in Rat Kidney with Ischemia-Reperfusion Injury.
C. W. YANG, S. W. LIM, K. W. HAN, H. J. AHN, J. H. PARK, Y. H. KIM, M. KIRSH, J. H. CHA, J. H. PARK, Y. S. KIM, et al. (2001)
J. Am. Soc. Nephrol. 12, 749-757
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Ciliary Neurotrophic Factor and Stress Stimuli Activate the Jak-STAT Pathway in Retinal Neurons and Glia.
W. M. Peterson, Q. Wang, R. Tzekova, and S. J. Wiegand (2000)
J. Neurosci. 20, 4081-4090
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LEDGF: Survival of Embryonic Chick Retinal Photoreceptor Cells.
M. Nakamura, D. P. Singh, E. Kubo, L. T. Chylack Jr, and T. Shinohara (2000)
Invest. Ophthalmol. Vis. Sci. 41, 1168-1175
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Intracellular and Extracellular Leukemia Inhibitory Factor Proteins Have Different Cellular Activities That Are Mediated by Distinct Protein Motifs.
B. P. Haines, R. B. Voyle, and P. D. Rathjen (2000)
Mol. Biol. Cell 11, 1369-1383
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Multiple Actions of Neurturin Correlate with Spatiotemporal Patterns of Ret Expression in Developing Chick Cranial Ganglion Neurons.
E. Hashino, E. M. Johnson Jr, J. Milbrandt, M. Shero, R. J. Salvi, and C. S. Cohan (1999)
J. Neurosci. 19, 8476-8486
   Abstract »    Full Text »    PDF »
Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor.
C. Bjørbæk, J. K. Elmquist, K. El-Haschimi, J. Kelly, R. S. Ahima, S. Hileman, and J. S. Flier (1999)
Endocrinology 140, 2035-2043
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Reciprocal Regulation of Ciliary Neurotrophic Factor Receptors and Acetylcholine Receptors during Synaptogenesis in Embryonic Chick Atria.
X. Wang and S. W. Halvorsen (1998)
J. Neurosci. 18, 7372-7380
   Abstract »    Full Text »    PDF »
Sexual Dimorphism in the Spinal Cord Is Absent in Mice Lacking the Ciliary Neurotrophic Factor Receptor.
N. G. Forger, M. L. Howell, L. Bengston, L. MacKenzie, T. M. DeChiara, and G. D. Yancopoulos (1997)
J. Neurosci. 17, 9605-9612
   Abstract »    Full Text »    PDF »
Endogenous Ciliary Neurotrophic Factor Is a Lesion Factor for Axotomized Motoneurons in Adult Mice.
M. Sendtner, R. Gotz, B. Holtmann, and H. Thoenen (1997)
J. Neurosci. 17, 6999-7006
   Abstract »    Full Text »    PDF »
Ciliary Neurotrophic Factor Stimulates the Phosphorylation of Two Forms of STAT3 in Chick Ciliary Ganglion Neurons.
M. A. Wishingrad, S. Koshlukova, and S. W. Halvorsen (1997)
J. Biol. Chem. 272, 19752-19757
   Abstract »    Full Text »    PDF »
Differential Regulation of Ciliary Neurotrophic Factor (CNTF) and CNTF Receptor alpha  Expression in Astrocytes and Neurons of the Fascia Dentata after Entorhinal Cortex Lesion.
M.-Y. Lee, T. Deller, M. Kirsch, M. Frotscher, and H.-D. Hofmann (1997)
J. Neurosci. 17, 1137-1146
   Abstract »    Full Text »    PDF »
Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina.
Z. Ezzeddine, X Yang, T DeChiara, G Yancopoulos, and C. Cepko (1997)
Development 124, 1055-1067
   Abstract »    PDF »
Alanine Substitution for Thr268 and Asp269 of Soluble Ciliary Neurotrophic Factor (CNTF) Receptor alpha Component Defines a Specific Antagonist for the CNTF Response.
P. Auguste, O. Robledo, C. Olivier, J. Froger, V. Praloran, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 26049-26056
   Abstract »    Full Text »    PDF »
Implants of Encapsulated Human CNTF-Producing Fibroblasts Prevent Behavioral Deficits and Striatal Degeneration in a Rodent Model of Huntington''s Disease.
D. F. Emerich, M. D. Lindner, S. R. Winn, E.-Y. Chen, B. R. Frydel, and J. H. Kordower (1996)
J. Neurosci. 16, 5168-5181
   Abstract »    Full Text »    PDF »
gp130 Transducing Receptor Cross-linking Is Sufficient to Induce Interleukin-6 Type Responses.
M. Fourcin, S. Chevalier, C. Guillet, O. Robledo, J. Froger, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 11756-11760
   Abstract »    Full Text »    PDF »
Cardiotrophin-1.
D. Pennica, K. J. Shaw, T. A. Swanson, M. W. Moore, D. L. Shelton, K. A. Zioncheck, A. Rosenthal, T. Taga, N. F. Paoni, and W. I. Wood (1995)
J. Biol. Chem. 270, 10915-10922
   Abstract »    Full Text »    PDF »
Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signaling.
R Stoop and M. Poo (1995)
Science 267, 695-699
   Abstract »    PDF »
Analysis of function and expression of the chick GPA receptor (GPAR alpha) suggests multiple roles in neuronal development.
S Heller, T. Finn, J Huber, R Nishi, M Geissen, A. Puschel, and H Rohrer (1995)
Development 121, 2681-2693
   Abstract »    PDF »
Binding Characteristics of Ciliary Neurotrophic Factor to Sympathetic Neurons and Neuronal Cell Lines.
V. Wong, D. Pearsall, R. Arriaga, N. Y. Ip, N. Stahl, and R. M. Lindsay (1995)
J. Biol. Chem. 270, 313-318
   Abstract »    Full Text »    PDF »
Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro.
M Mayer, K Bhakoo, and M Noble (1994)
Development 120, 143-153
   Abstract »    PDF »
Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.
J. Conover, N. Ip, W. Poueymirou, B Bates, M. Goldfarb, T. DeChiara, and G. Yancopoulos (1993)
Development 119, 559-565
   Abstract »    PDF »
Multiple cholinergic differentiation factors are present in footpad extracts: comparison with known cholinergic factors.
M. Rao, P. Patterson, and S. Landis (1992)
Development 116, 731-744
   Abstract »    PDF »
Cloning and Analysis of Neurotrophic Factor Receptors Using Function-based Strategies.
D.J. Glass, D.R. Gies, T. Stitt, S. Davis, P. Hantzopoulos, N.Y. Ip, M. Goldfarb, and G.D. Yancopoulos (1992)
Cold Spring Harb Symp Quant Biol 57, 53-62
   Abstract »    PDF »
The receptor for ciliary neurotrophic factor.
S Davis, T. Aldrich, D. Valenzuela, V. Wong, M. Furth, S. Squinto, and G. Yancopoulos (1991)
Science 253, 59-63
   Abstract »    PDF »
Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor.
R. Oppenheim, D Prevette, Q. Yin, F Collins, and J MacDonald (1991)
Science 251, 1616-1618
   Abstract »    PDF »
Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity.
Y. Li, P. Milner, A. Chauhan, M. Watson, R. Hoffman, C. Kodner, J Milbrandt, and T. Deuel (1990)
Science 250, 1690-1694
   Abstract »    PDF »
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
P. Maisonpierre, L Belluscio, S Squinto, N. Ip, M. Furth, R. Lindsay, and G. Yancopoulos (1990)
Science 247, 1446-1451
   Abstract »    PDF »
An Analysis of the Cell-Cell Interactions That Control the Proliferation and Differentiation of a Bipotential Glial Progenitor Cell in Culture.
M.C. Raff, I.K. Hart, W.D. Richardson, and L.E. Lillien (1990)
Cold Spring Harb Symp Quant Biol 55, 235-238
   Abstract »    PDF »
Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis.
H. Nawa, T. Yamamori, T. Le, and P.H. Patterson (1990)
Cold Spring Harb Symp Quant Biol 55, 247-253
   Abstract »    PDF »
Neurotrophic Factors, Their Receptors, and the Signal Transduction Pathways They Activate.
G.D. Yancopoulos, P.C. Maisonpierre, N.Y. Ip, T.H. Aldrich, L. Belluscio, T.G. Boulton, M.H. Cobb, S.R Squinto, and M.E. Furth (1990)
Cold Spring Harb Symp Quant Biol 55, 371-379
   Abstract »    PDF »
Signaling Pathways Recruited by the Cardiotrophin-like Cytokine/Cytokine-like Factor-1 Composite Cytokine. SPECIFIC REQUIREMENT OF THE MEMBRANE-BOUND FORM OF CILIARY NEUROTROPHIC FACTOR RECEPTOR alpha COMPONENT.
E. Lelievre, H. Plun-Favreau, S. Chevalier, J. Froger, C. Guillet, G. C. A. Elson, J.-F. Gauchat, and H. Gascan (2001)
J. Biol. Chem. 276, 22476-22484
   Abstract »    Full Text »    PDF »


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