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Science 24 November 1989:
Vol. 246. no. 4933, pp. 1034 - 1038
DOI: 10.1126/science.2511628
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Articles

Science, Vol 246, Issue 4933, 1034-1038
Copyright © 1989 by American Association for the Advancement of Science

articles

Similarity between the transcriptional silencer binding proteins ABF1 and RAP1

JF Diffley and B Stillman

Cold Spring Harbor Laboratory, NY 11724.

The yeast ARS binding factor 1 (ABF1)--where ARS is an autonomously replicating sequence--and repressor/activator protein 1 (RAP1) have been implicated in DNA replication, transcriptional activation, and transcriptional silencing. The ABF1 gene was cloned and sequenced and shown to be essential for viability. The predicted amino acid sequence contains a novel sequence motif related to the zinc finger, and the ABF1 protein requires zinc and unmodified cysteine residues for sequence-specific DNA binding. Interestingly, ABF1 is extensively related to its counterpart, RAP1, and both proteins share a region of similarity with SAN1, a suppressor of certain SIR4 mutations, suggesting that this region may be involved in mediating SIR function at the silent mating type loci.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ABF1-binding Sites Promote Efficient Global Genome Nucleotide Excision Repair.
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J. Biol. Chem. 284, 966-973
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Subtelomeric Elements Influence But Do Not Determine Silencing Levels at Saccharomyces cerevisiae Telomeres.
M. A. Mondoux and V. A. Zakian (2007)
Genetics 177, 2541-2546
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Purification of the yeast Slx5-Slx8 protein complex and characterization of its DNA-binding activity.
L. Yang, J. R. Mullen, and S. J. Brill (2006)
Nucleic Acids Res. 34, 5541-5551
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Structural basis for origin recognition complex 1 protein-silence information regulator 1 protein interaction in epigenetic silencing.
H.-C. Hsu, B. Stillman, and R.-M. Xu (2005)
PNAS 102, 8519-8524
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The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription.
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Comparison of ABF1 and RAP1 in Chromatin Opening and Transactivator Potentiation in the Budding Yeast Saccharomyces cerevisiae.
A. Yarragudi, T. Miyake, R. Li, and R. H. Morse (2004)
Mol. Cell. Biol. 24, 9152-9164
   Abstract »    Full Text »    PDF »
Genome-wide Analysis of ARS (Autonomously Replicating Sequence) Binding Factor 1 (Abf1p)-mediated Transcriptional Regulation in Saccharomyces cerevisiae.
T. Miyake, J. Reese, C. M. Loch, D. T. Auble, and R. Li (2004)
J. Biol. Chem. 279, 34865-34872
   Abstract »    Full Text »    PDF »
Telomere Repeat Binding Factors TRF1, TRF2, and hRAP1 Modulate Replication of Epstein-Barr Virus OriP.
Z. Deng, C. Atanasiu, J. S. Burg, D. Broccoli, and P. M. Lieberman (2003)
J. Virol. 77, 11992-12001
   Abstract »    Full Text »    PDF »
Slx1--Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1--Top3.
W. M. Fricke and S. J. Brill (2003)
Genes & Dev. 17, 1768-1778
   Abstract »    Full Text »    PDF »
Identification of a Multifunctional Domain in Autonomously Replicating Sequence-Binding Factor 1 Required for Transcriptional Activation, DNA Replication, and Gene Silencing.
T. Miyake, C. M. Loch, and R. Li (2002)
Mol. Cell. Biol. 22, 505-516
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Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair.
S. H. Reed, M. Akiyama, B. Stillman, and E. C. Friedberg (1999)
Genes & Dev. 13, 3052-3058
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Synergistic Operation of the CAR2 (Ornithine Transaminase) Promoter Elements in Saccharomyces cerevisiae.
H.-D. Park, S. Scott, R. Rai, R. Dorrington, and T. G. Cooper (1999)
J. Bacteriol. 181, 7052-7064
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Identification and Characterization of the Fourth Single-Stranded-DNA Binding Domain of Replication Protein A.
S. J. Brill and S. Bastin-Shanower (1998)
Mol. Cell. Biol. 18, 7225-7234
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Transcriptional Regulation of the SMK1 Mitogen-Activated Protein Kinase Gene during Meiotic Development in Saccharomyces cerevisiae.
M. Pierce, M. Wagner, J. Xie, V. Gailus-Durner, J. Six, A. K. Vershon, and E. Winter (1998)
Mol. Cell. Biol. 18, 5970-5980
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Genetic Tests of the Role of Abf1p in Driving Transcription of the Yeast TATA Box Bindng Protein-encoding Gene, SPT15.
S. C. Schroeder and P. A. Weil (1998)
J. Biol. Chem. 273, 19884-19891
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The Transcriptional Activators BAS1, BAS2, and ABF1 Bind Positive Regulatory Sites as the Critical Elements for Adenine Regulation of ADE5,7.
R. J. Rolfes, F. Zhang, and A. G. Hinnebusch (1997)
J. Biol. Chem. 272, 13343-13354
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Binding Sites for Abundant Nuclear Factors Modulate RNA Polymerase I-dependent Enhancer Function in Saccharomyces cerevisiae.
J. J. Kang, T. J. Yokoi, and M. J. Holland (1995)
J. Biol. Chem. 270, 28723-28732
   Abstract »    Full Text »    PDF »
Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast..
S W Buck and D Shore (1995)
Genes & Dev. 9, 370-384
   Abstract »    PDF »
Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1..
P Moretti, K Freeman, L Coodly, and D Shore (1994)
Genes & Dev. 8, 2257-2269
   Abstract »    PDF »
DNA bending and orientation-dependent function of YY1 in the c-fos promoter..
S Natesan and M Z Gilman (1993)
Genes & Dev. 7, 2497-2509
   Abstract »    PDF »
A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation..
C F Hardy, L Sussel, and D Shore (1992)
Genes & Dev. 6, 801-814
   Abstract »    PDF »
A yeast chromosomal origin of DNA replication defined by multiple functional elements.
Y Marahrens and B Stillman (1992)
Science 255, 817-823
   Abstract »    PDF »


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