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Science 24 November 1989:
Vol. 246. no. 4933, pp. 1038 - 1041
DOI: 10.1126/science.2511629
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Articles

Science, Vol 246, Issue 4933, 1038-1041
Copyright © 1989 by American Association for the Advancement of Science

articles

A nondeletional mechanism of thymic self tolerance

F Ramsdell, T Lantz, and BJ Fowlkes

Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892.

T cells become tolerant of self antigens during their development in the thymus. Clonal deletion of thymocytes bearing self-reactive T cell receptors is a major mechanism for generating tolerance and occurs readily for antigens expressed by bone marrow-derived cells. Tolerance to antigens expressed on the radioresistant thymic stromal elements is demonstrated here to occur via a nondeletional mechanism. For minor lymphocyte stimulatory (Mls-1a) and major histocompatibility complex (MHC) antigens, this alternate form of tolerance induction results in clonal anergy.


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