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Science 1 December 1989:
Vol. 246. no. 4934, pp. 1158 - 1161
DOI: 10.1126/science.2588000
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Articles

Science, Vol 246, Issue 4934, 1158-1161
Copyright © 1989 by American Association for the Advancement of Science

articles

1,25-dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene

NA Morrison, J Shine, JC Fragonas, V Verkest, ML McMenemy, and JA Eisman

Garvan Institute of Medical Research, St. Vincents Hospital, Sydney, Australia.

The active hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3[1,25(OH), which regulates cellular replication and function in many tissues and has a role in bone and calcium homeostasis, acts through a hormone receptor homologous with other steroid and thyroid hormone receptors. A 1,25(OH)2D3-responsive element (VDRE), which is within the promoter for osteocalcin [a bone protein induced by 1,25(OH)2D3] is unresponsive to other steroid hormones, can function in a heterologous promoter, and contains a doubly palindromic DNA sequence (TTGGTGACTCACCGGGTGAAC; -513 to -493 bp), with nucleotide sequence homology to other hormone responsive elements. The potent glucocorticoid repression of 1,25(OH)2D3 induction and of basal activity of this promoter acts through a region between -196 and +34 bp, distinct from the VDRE.


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