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Science 8 December 1989: Vol. 246. no. 4935, pp. 1306 - 1309 DOI: 10.1126/science.2479986
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Articles
Science, Vol 246, Issue 4935, 1306-1309
Copyright © 1989 by American Association for the Advancement of Science
Vascular endothelial growth factor is a secreted angiogenic mitogen
DW Leung,
G Cachianes,
WJ Kuang,
DV Goeddel,
and
N Ferrara
Department of Molecular Biology, Genetech, South San Francisco, CA 94080.
Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC). VEGF is a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo. Complementary DNA clones for bovine and human VEGF were isolated from cDNA libraries prepared from FC and HL60 leukemia cells, respectively. These cDNAs encode hydrophilic proteins with sequences related to those of the A and B chains of platelet-derived growth factor. DNA sequencing suggests the existence of several molecular species of VEGF. VEGFs are secreted proteins, in contrast to other endothelial cell mitogens such as acidic or basic fibroblast growth factors and platelet-derived endothelial cell growth factor. Human 293 cells transfected with an expression vector containing a bovine or human VEGF cDNA insert secrete an endothelial cell mitogen that behaves like native VEGF.
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- K. Nasu, H. Itoh, A. Yuge, Y. Kawano, and H. Narahara (2006)
Reproductive Sciences
13, 368-371
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- Remodeling in asthma and chronic obstructive pulmonary disease..
- D. S. Postma and W. Timens (2006)
Proceedings of the ATS
3, 434-439
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- Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?.
- A R L Medford and A B Millar (2006)
Thorax
61, 621-626
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- Effects of peritoneal fluid from endometriosis patients on the release of vascular endothelial growth factor by neutrophils and monocytes.
- Y.-J. Na, S.-H. Yang, D.-W. Baek, D.-H. Lee, K.-H. Kim, Y.-M. Choi, S.-T. Oh, Y.-S. Hong, J.-Y. Kwak, and K.-S. Lee (2006)
Hum. Reprod.
21, 1846-1855
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- Dimethylarginine Dimethylaminohydrolase 2 Increases Vascular Endothelial Growth Factor Expression Through Sp1 Transcription Factor in Endothelial Cells.
- K. Hasegawa, S. Wakino, T. Tanaka, M. Kimoto, S. Tatematsu, T. Kanda, K. Yoshioka, K. Homma, N. Sugano, M. Kurabayashi, et al. (2006)
Arterioscler. Thromb. Vasc. Biol.
26, 1488-1494
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- Model of Vasculogenesis from Embryonic Stem Cells for Vascular Research and Regenerative Medicine.
- H. Nakagami, N. Nakagawa, Y. Takeya, K. Kashiwagi, C. Ishida, S.-i. Hayashi, M. Aoki, K. Matsumoto, T. Nakamura, T. Ogihara, et al. (2006)
Hypertension
48, 112-119
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- Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality.
- K. Yano, P. C. Liaw, J. M. Mullington, S.-C. Shih, H. Okada, N. Bodyak, P. M. Kang, L. Toltl, B. Belikoff, J. Buras, et al. (2006)
J. Exp. Med.
203, 1447-1458
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- Hepatocyte Growth Factor Induces Retinal Vascular Permeability via MAP-Kinase and PI-3 Kinase without Altering Retinal Hemodynamics..
- A. C. Clermont, M. Cahill, H. Salti, S. L. Rook, C. Rask-Madsen, L. Goddard, J. S. Wong, D. Bursell, S. E. Bursell, and L. P. Aiello (2006)
Invest. Ophthalmol. Vis. Sci.
47, 2701-2708
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- Differential effects of selective endothelin type a receptor antagonist on the gene expression of vascular endothelial growth factor and its receptors in streptozotocin-induced diabetic heart..
- S. Jesmin, S. Zaedi, N. Yamaguchi, S. Maeda, N. Shimojo, K. Masuzawa, I. Yamaguchi, K. Goto, and T. Miyauchi (2006)
Experimental Biology and Medicine
231, 902-906
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- A Novel Noninvasive Model of Endometriosis for Monitoring the Efficacy of Antiangiogenic Therapy.
- C. M. Becker, R. D. Wright, R. Satchi-Fainaro, T. Funakoshi, J. Folkman, A. L. Kung, and R. J. D'Amato (2006)
Am. J. Pathol.
168, 2074-2084
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- Neovascularization in Human Atherosclerosis.
- P. R. Moreno, K-R. Purushothaman, M. Sirol, A. P. Levy, and V. Fuster (2006)
Circulation
113, 2245-2252
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- The Role of PDGF Receptor Inhibitors and PI3-Kinase Signaling in the Pathogenesis of Corneal Neovascularization.
- S. Dell, S. Peters, P. Muther, N. Kociok, and A. M. Joussen (2006)
Invest. Ophthalmol. Vis. Sci.
47, 1928-1937
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